4.2 Article

Mitochondrial Localization of CB1 in Progesterone-producing Cells of Ovarian Interstitial Glands of Adult Mice

Journal

JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
Volume 70, Issue 3, Pages 251-257

Publisher

SAGE PUBLICATIONS LTD
DOI: 10.1369/00221554211063516

Keywords

CB1; mitochondria; ovary; steroidogenic cell

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Funding

  1. Faculty of Medicine, Khon Kaen University, Thailand [IN63338]

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The study found that cannabinoid receptor type 1 (CB1) is localized on mitochondrial membranes in ovarian interstitial gland cells of adult mice, potentially modulating the synthetic process of progesterone through CB1.
Localization of cannabinoid receptor type 1 (CB1) immunoreactivity on mitochondrial membranes, at least their outer membranes distinctly, was detected in progesterone-producing cells characterized by mitochondria having tubular cristae and aggregations of lipid droplets in ovarian interstitial glands in situ of adult mice. Both immunoreactive and immunonegative mitochondria were contained in one and the same cell. Considering that the synthesis of progesterone is processed in mitochondria, the mitochondrial localization of CB1 in the interstitial gland cells suggests the possibility that endocannabinoids modulate the synthetic process of progesterone in the cells through CB1:

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