Journal
JOURNAL OF HETEROCYCLIC CHEMISTRY
Volume 59, Issue 2, Pages 239-257Publisher
WILEY
DOI: 10.1002/jhet.4382
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Heterocyclic rings, especially quinazolinone derivatives, have attracted the interest of medicinal chemists for their potential pharmacological activities. These compounds have shown promising results in various fields, such as anticancer, anti-inflammatory, and antibacterial properties. Extensive literature and patent information on the synthetic schemes and biological activities of quinazolinone have been explored in this study.
Heterocyclic rings have long piqued the interest of medicinal chemists. Quinazolinone is a fused nitrogen-based heterocyclic moiety. Some of quinazolinone derivatives have emerged as marketed drugs. A tremendous number of pharmacological activities such as anticancer, anticonvulsant, antimalarial, antifungal, antibacterial, antiinflammatory, MMP inhibitors, antidiabetic, antileishmanial, and hypolipidemic properties have been explored. A number of quinazolinone derivatives have already paved way in various stages of clinical trials. An extensive literature on developed synthetic schemes based on green chemistry and biological activities of quinazolinone has been included in this study. The content of patent filed and granted of various quinazolinone-based compounds are also mentioned.
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