Journal
JOURNAL OF HETEROCYCLIC CHEMISTRY
Volume 59, Issue 2, Pages 388-393Publisher
WILEY
DOI: 10.1002/jhet.4390
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This study presents a facile and environmentally friendly method for the synthesis of a novel compound utilizing a chitosan-catalyzed three-component reaction in water. The method offers advantages such as readily available starting materials, simple operation, and reusable catalyst.
A facile, one-pot, environmentally benign and chitosan-catalyzed protocol for the construction of a novel 3,3 '-diheterocycle substituted oxindole framework by three-component reaction between 3-pyrazolyl-oxindoles, salicylaldehydes, and malononitrile in water is reported. This protocol provides several advantages including readily available starting materials, a simple operation, without the need of purification by column chromatography, reusable catalyst.
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