4.8 Article

Systemic treatment of hepatocellular carcinoma: An EASL position paper

Related references

Note: Only part of the references are listed.
Article Gastroenterology & Hepatology

Hyperprogressive disease during PD-1 blockade in patients with advanced hepatocellular carcinoma

Chang Gon Kim et al.

Summary: HPD can occur in a fraction of HCC patients treated with PD-1 inhibitors, leading to worse survival outcomes and missed treatment opportunities for the majority of affected patients. Analyzing baseline immune profiles and tumor growth dynamics during treatment could help identify HPD earlier for optimal patient management.

JOURNAL OF HEPATOLOGY (2021)

Article Radiology, Nuclear Medicine & Medical Imaging

Radiological response to nivolumab in patients with hepatocellular carcinoma: A multicenter analysis of real-life practice

Jordi Rimola et al.

Summary: This study analyzed the radiological response in 31 hepatocellular carcinoma patients treated with nivolumab, finding heterogeneous imaging findings both between and within patients. Disease progression does not always indicate treatment failure, and surrogate end-points may not accurately reflect survival outcomes.

EUROPEAN JOURNAL OF RADIOLOGY (2021)

Article Gastroenterology & Hepatology

Endpoints in clinical trials for liver cancer and their value in evidence-based clinical decision making: An unresolved Gordian knot

Jordi Bruix

Summary: Clinical trials rely on strict definitions and criteria, but real-world clinical practice may not follow the same guidelines, leading to discrepancies in patient selection, disease assessment, and treatment decisions. Understanding these differences is crucial in refining criteria for drug activity, toxicity, and treatment failure in order to achieve evidence-based clinical practice and precision oncology.

JOURNAL OF HEPATOLOGY (2021)

Article Oncology

Sintilimab plus a bevacizumab biosimilar (IBI305) versus sorafenib in unresectable hepatocellular carcinoma (ORIENT-32): a randomised, open-label, phase 2-3 study

Zhenggang Ren et al.

Summary: The study aimed to assess the efficacy of sintilimab plus IBI305 versus sorafenib as a first-line treatment for unresectable HBV-associated hepatocellular carcinoma in China, showing significant overall survival and progression-free survival benefits with acceptable safety profiles.

LANCET ONCOLOGY (2021)

Editorial Material Medicine, General & Internal

When Can Intermediate Outcomes Be Used as Surrogate Outcomes?

David L. DeMets et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

Review Gastroenterology & Hepatology

Diagnosis and management of toxicities of immune checkpoint inhibitors in hepatocellular carcinoma

Bruno Sangro et al.

JOURNAL OF HEPATOLOGY (2020)

Article Medicine, Research & Experimental

Comparative Efficacy of Cabozantinib and Regorafenib for Advanced Hepatocellular Carcinoma

Robin K. Kelley et al.

ADVANCES IN THERAPY (2020)

Article Cardiac & Cardiovascular Systems

The Pattern of Progression Defines Post-progression Survival in Patients with Hepatocellular Carcinoma Treated with SIRT

Manuel de la Torre-Alaez et al.

CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY (2020)

Article Gastroenterology & Hepatology

International and multicenter real-world study of sorafenib-treated patients with hepatocellular carcinoma under dialysis

Alvaro Diaz-Gonzalez et al.

LIVER INTERNATIONAL (2020)

Article Medicine, General & Internal

Atezolizumab plus Bevacizumab in Unresectable Hepatocellular Carcinoma

Richard S. Finn et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Article Oncology

Treatment after progression in the era of immunotherapy

Salem Billan et al.

LANCET ONCOLOGY (2020)

Article Gastroenterology & Hepatology

Long-term observation of hepatocellular carcinoma recurrence after liver transplantation at a European transplantation centre

Friedrich Foerster et al.

UNITED EUROPEAN GASTROENTEROLOGY JOURNAL (2019)

Article Medicine, General & Internal

Assessment of the Clinical Benefit of Cancer Drugs Receiving Accelerated Approval

Bishal Gyawali et al.

JAMA INTERNAL MEDICINE (2019)

Review Gastroenterology & Hepatology

Randomized trials and endpoints in advanced HCC: Role of PFS as a surrogate of survival

Josep M. Llovet et al.

JOURNAL OF HEPATOLOGY (2019)

Review Gastroenterology & Hepatology

Insights into the success and failure of systemic therapy for hepatocellular carcinoma

Jordi Bruix et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2019)

Review Oncology

Novel patterns of response under immunotherapy

E. Borcoman et al.

ANNALS OF ONCOLOGY (2019)

Review Gastroenterology & Hepatology

Clinical states of cirrhosis and competing risks

Gennaro D'Amico et al.

JOURNAL OF HEPATOLOGY (2018)

Article Gastroenterology & Hepatology

EASL Clinical Practice Guidelines: Management of hepatocellular carcinoma

Peter R. Galle et al.

JOURNAL OF HEPATOLOGY (2018)

Review Medicine, General & Internal

Hepatocellular carcinoma

Alejandro Forner et al.

LANCET (2018)

Article Medicine, General & Internal

Cabozantinib in Patients with Advanced and Progressing Hepatocellular Carcinoma

G. K. Abou-Alfa et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Review Gastroenterology & Hepatology

Use of checkpoint inhibitors in liver transplant recipients

Stefan Munker et al.

UNITED EUROPEAN GASTROENTEROLOGY JOURNAL (2018)

Article Oncology

RECIST-learning from the past to build the future

Saskia Litiere et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2017)

Editorial Material Gastroenterology & Hepatology

Assessment of treatment efficacy in hepatocellular carcinoma: Response rate, delay in progression or none of them

Jordi Bruix et al.

JOURNAL OF HEPATOLOGY (2017)

Article Gastroenterology & Hepatology

Objective response by mRECIST as a predictor and potential surrogate end-point of overall survival in advanced HCC

Riccardo Lencioni et al.

JOURNAL OF HEPATOLOGY (2017)

Article Gastroenterology & Hepatology

Early dermatologic adverse events predict better outcome in HCC patients treated with sorafenib

Maria Reig et al.

JOURNAL OF HEPATOLOGY (2014)

Article Gastroenterology & Hepatology

Usefulness of alpha-fetoprotein response in patients treated with sorafenib for advanced hepatocellular carcinoma

Nicola Personeni et al.

JOURNAL OF HEPATOLOGY (2012)

Editorial Material Oncology

When Progressive Disease Does Not Mean Treatment Failure: Reconsidering the Criteria for Progression

Geoffrey R. Oxnard et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2012)

Review Oncology

Biomarkers and surrogate end points-the challenge of statistical validation

Marc Buyse et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2010)

Review Gastroenterology & Hepatology

Modified RECIST (mRECIST) Assessment for Hepatocellular Carcinoma

Riccardo Lencioni et al.

SEMINARS IN LIVER DISEASE (2010)

Article Oncology

New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1)

E. A. Eisenhauer et al.

EUROPEAN JOURNAL OF CANCER (2009)

Article Gastroenterology & Hepatology

Safety and Efficacy of Sorafenib in Patients With Advanced Hepatocellular Carcinoma in Consideration of Concomitant Stage of Liver Cirrhosis

Marcus Alexander Wörns et al.

JOURNAL OF CLINICAL GASTROENTEROLOGY (2009)

Article Medicine, General & Internal

Sorafenib in advanced hepatocellular carcinoma

Josep M. Llovet et al.

NEW ENGLAND JOURNAL OF MEDICINE (2008)

Review Gastroenterology & Hepatology

Clinical management of hepatocellular carcinoma.: Conclusions of the Barcelona-2000 EASL Conference

J Bruix et al.

JOURNAL OF HEPATOLOGY (2001)