Presence of pharmaceuticals and their metabolites in wild-living aquatic organisms - Current state of knowledge

In the last decades an increasing number of studies has been published concerning contamination of aquatic ecosystems with pharmaceuticals. Yet, the distribution of these chemical compounds in aquatic environments raises many questions and uncertainties. Data on the presence of selected pharmaceuticals in the same water bodies varies significantly between different studies. Therefore, since early 1990 s, wild organisms have been used in research on environmental contamination with pharmaceuticals. Indeed, pharmaceutical levels measured in biological matrices may better reflect their overall presence in the aquatic environments as such levels include not only direct exposure of a given organisms to a specific pollutant but also processes such as bioaccumulation and biomagnification. In the present paper, data concerning occurrence of pharmaceuticals in aquatic biota was reviewed. So far, pharmaceuticals have been studied mainly in fish and molluscs, with only a few papers available on crustaceans and macroalgae. The most commonly found pharmaceuticals both in freshwater and marine organisms are antibiotics, antidepressants and NSAIDS while there is no information about the presence of anticancer drugs in aquatic organisms. Furthermore, only single studies were conducted in Africa and Australia. Hence, systematization of up-to-date knowledge, the main aim of this review, is needed for further research targeting.

Automated summary

In recent years, there has been a growing number of studies on pharmaceutical contamination of aquatic ecosystems, but questions and uncertainties remain regarding the distribution of these chemicals in water environments. Variability in data on the presence of pharmaceuticals in water bodies highlights the need for further research on the topic. Wild organisms have been used as research subjects since the early 1990s to study environmental contamination with pharmaceuticals, with a focus on the measurement of pharmaceutical levels in biological matrices to better understand their overall presence in aquatic environments.