Journal
JOURNAL OF HAZARDOUS MATERIALS
Volume 422, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.jhazmat.2021.126930
Keywords
Dimetridazole (DMZ); Ornidazole (ONZ); Degradation mechanism; Kinetic computation; Toxicity evaluation
Categories
Funding
- National Natural Science Foundation of China [21507027, 21707062, 41775119, 51801058]
- Postgraduate Innovative Scientific Research Construction Project of Hubei Normal University [20210114]
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DMZ and ONZ residues in the water environment can be degraded by hydroxyl-initiated oxidation, resulting in degradation products that may be toxic to aquatic organisms in the first step but generally harmless in subsequent steps, with some products showing potential developmental toxicant or mutagenicity.
Dimetridazole (DMZ) and ornidazole (ONZ) have been widely used to treat anaerobic and protozoal infections. The residues of DMZ/ONZ persist in the water environment. The mechanisms and kinetics of hydroxyl-initiated oxidation, the primary DMZ/ONZ degradation method, were evaluated by quantum chemical methods center dot OHinduced degradation of DMZ and ONZ shared many mechanistic and kinetic characteristics. The most feasible degradation pathway involved forming OH-imidazole adducts and NO2. The OH-imidazole adducts were subsequently degraded into double center dot OH imidazole intermediates. The rate coefficients for center dot OH degradation of DMZ and ONZ were 4.32 x 10(9) M-1 s(-1) and 4.42 x 10(9) M-1 s(-1) at 298 K, respectively. The lifetimes of DMZ and ONZ treated with center dot OH at concentrations of 10(-9)-10(-18) mol L-1 at 298 K were tau(DMZ) = 0.231-2.31 x 10(8) s and tau(ONZ) = 0.226-2.26 x 10(8) s, respectively. Toxicity assessment showed that the first degradation products of DMZ and ONZ exhibited enhanced aquatic toxicity, whereas most of the secondary degradation products were not harmful to aquatic organisms. Some of transformation products were still developmental toxicant or mutagenicity positive.
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