New Polymerizable Tetraaza Macrocycle Containing Two Acridine Units for Selective Fluorescence Sensing of Metal Ions

A new fluorescent bis(acridino)-macrocycle containing two allyl groups was synthesized and photophysically studied. Studies were carried out on metal ion recognition and selectivity-influencing effects including the determination of the relevant thermodynamic constants as logK and pK(a). The proposed sensor molecule is recommended for the development of Zn2+-selective optochemical analyzers based on covalently immobilized ionophores as it has a unique pH-independent metal ion recognition ability, which is not influenced by anions and other potentially occurring metal ions in biological samples.

Automated summary

A new fluorescent bis(acridino)-macrocycle with two allyl groups was synthesized and studied for metal ion recognition and selectivity effects, determining important thermodynamic constants. The sensor molecule is recommended for Zn2+ -selective optochemical analyzers based on covalently immobilized ionophores due to its unique pH-independent metal ion recognition ability unaffected by anions and other potentially occurring metal ions in biological samples.