Journal
JOURNAL OF FISH DISEASES
Volume 45, Issue 3, Pages 479-483Publisher
WILEY
DOI: 10.1111/jfd.13556
Keywords
ASK; HPR0; ISAV; Salmo salar; SHK-1; virus isolation
Funding
- National Aquatic Animal Health Program
- Fisheries and Oceans Canada
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ISAV is the causative agent of infectious salmon anaemia (ISA) which has caused significant economic losses to the Atlantic salmon industry. ISAV variants are identified as pathogenic or non-pathogenic based on the presence or absence of a deletion in the highly polymorphic region (HPR) of segment 6 (S6).
ISAV is the causative agent of the infectious salmon anaemia (ISA), a disease listed by the OIE that has caused important economic losses to the Atlantic salmon (Salmo salar) industry. ISAV variants are identified as pathogenic or non-pathogenic based on the presence or absence of a deletion in the highly polymorphic region (HPR) of segment 6 (S6). HPR Delta variants (pathogenic) are the only forms of the virus known to grow in cell culture. This is the first report of a HPR0 variant isolated in cell culture. The isolate is, however, atypical as it shows a marker of virulent variants on another segment (S5), which has never been reported for any other HPR0 variants. The significance of this finding remains unclear until more in-depth work is carried out but does challenge current knowledge.
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