4.7 Editorial Material

Germinal center derived B cell memory without T cells

Journal

JOURNAL OF EXPERIMENTAL MEDICINE
Volume 219, Issue 3, Pages -

Publisher

ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20220012

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Funding

  1. Biotechnology and Biological Sciences Research Council [BB/S003800/1]

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Liu et al. demonstrate in this study that T cell-independent germinal centers can generate long-lived memory cells and plasma cell output, which may explain the long-term protection provided by polysaccharide antigens.
Liu et al. (2022. J. Exp. Med.https://doi.org/10.1084/jem.20210527) in this issue show that T cell-independent germinal centers (GCs) can produce long-lived memory and plasma cell output. This may help explain how polysaccharide antigens provide long-term protection.

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