4.7 Review

Immunotherapy for glioblastoma: the promise of combination strategies

Related references

Note: Only part of the references are listed.
Review Oncology

A review of glioblastoma immunotherapy

Ravi Medikonda et al.

Summary: Current immunotherapy treatments for glioblastoma, including checkpoint inhibitors and vaccine therapy, have shown disappointing results in clinical trials due to the highly immunosuppressive environment and therapy resistance mechanisms of the tumor. Ongoing research is focusing on exploring combination therapies and novel treatment strategies beyond immune checkpoint therapies, as well as establishing synergy between immunotherapy and current standard of care to improve treatment outcomes. Recent advances in personalized neoantigen vaccines suggest a shift towards personalized, patient-specific treatment for glioblastoma.

JOURNAL OF NEURO-ONCOLOGY (2021)

Review Pharmacology & Pharmacy

Rationally designed drug delivery systems for the local treatment of resected glioblastoma

Chiara Bastiancich et al.

Summary: Local drug delivery is an effective way to treat GBM, allowing for immediate post-surgery treatment and bypassing the blood-brain barrier to reduce systemic side effects. Rational design of biomaterials and drug delivery systems is crucial for preventing tumor recurrence.

ADVANCED DRUG DELIVERY REVIEWS (2021)

Article Biotechnology & Applied Microbiology

Gemcitabine and doxorubicin in immunostimulatory monophosphoryl lipid A liposomes for treating breast cancer

Debra Wu et al.

Summary: Cancer therapy is increasingly focusing on targeting the tumor immune microenvironment, with chemotherapy inducing immunostimulatory responses that can be enhanced by immune-modulating agents. However, long-term immune responses may be lacking in some cases, despite initial efficacy against tumors.

BIOENGINEERING & TRANSLATIONAL MEDICINE (2021)

Review Biochemistry & Molecular Biology

Emerging Approaches for Solid Tumor Treatment Using CAR-T Cell Therapy

Hyunmin Chung et al.

Summary: CAR-T cell therapy is increasingly important in cancer treatment, especially for cancers resistant to conventional chemotherapy. The therapy has shown promising results in hematologic malignancies, but its efficacy in solid tumors still needs further evaluation and improvement.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Nanoscience & Nanotechnology

Immunogenic Cell Death Induced by Chemoradiotherapy of Novel pH-Sensitive Cargo-Loaded Polymersomes in Glioblastoma

Chen He et al.

Summary: The novel pH-sensitive cargo-loaded polymersomes have been shown to effectively induce immunogenic cell death and synergize with radiotherapy, holding potential significance for cancer therapy.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2021)

Review Oncology

Immunocompetent Mouse Models in the Search for Effective Immunotherapy in Glioblastoma

Roxanne Wouters et al.

Summary: Glioblastoma remains a highly aggressive brain tumor with limited treatment options, despite the advancements in preclinical immunotherapeutic approaches. The discrepancy between successful animal experiments and clinical trials may be attributed to the inability of current mouse models to fully replicate the complexity and heterogeneity of the disease. Understanding and combining different mouse models may be crucial in capturing the full spectrum of GBM for effective research and drug testing.

CANCERS (2021)

Review Oncology

Adenosinergic Pathway: A Hope in the Immunotherapy of Glioblastoma

Ketao Jin et al.

Summary: Glioblastoma multiforme (GBM) is an aggressive type of brain tumor with poor response to traditional therapies. The immunosuppressive microenvironment in GBM poses a challenge for immunotherapy, with the adenosinergic pathway playing a key role in suppressing antitumor immune responses. Targeting this pathway in combination therapies shows promise in reinvigorating antitumor responses and overcoming chemoresistance.

CANCERS (2021)

Review Cell Biology

Myeloid Cells in Glioblastoma Microenvironment

Alessandra De Leo et al.

Summary: Glioblastoma (GBM) is a highly aggressive and malignant brain tumor with a unique immune microenvironment that is resistant to immunotherapy. Myeloid cells play a crucial role in regulating immune and therapeutic responses in GBM. Studying the characteristics and functions of different populations of myeloid cells in GBM offers new insights for targeting specific cells for therapeutic purposes.

CELLS (2021)

Review Engineering, Biomedical

Biocompatible copolymer formulations to treat glioblastoma multiforme

Luiza C. S. Erthal et al.

Summary: The treatment for GBM has remained unchanged for over 20 years, with surgery, radiotherapy, and chemotherapy being the standard of care. Research is now focused on improving treatment outcomes and patient quality of life, with a particular emphasis on biomaterials such as hydrogels for new treatment options. Various formulations, including biocompatible polymers for injectable and localized therapies, are being developed and tested to enhance the localized treatment of GBM. Biomaterial formulations offer potential for better treatment outcomes for glioblastoma patients in the future.

ACTA BIOMATERIALIA (2021)

Article Chemistry, Multidisciplinary

ImmunoPET-informed sequence for focused ultrasound-targeted mCD47 blockade controls glioma

Natasha D. Sheybani et al.

Summary: Phagocytic immunotherapies, such as CD47 blockade, have shown promise in treating glioblastoma (GB). Overcoming the challenges posed by the blood brain/tumor barriers (BBB/BTB) for mCD47 delivery through focused ultrasound (FUS) is crucial. Timing of antibody injection relative to FUS BBB/BTB disruption is essential for optimal mCD47 access to gliomas. Repeat sessions of FUS can significantly constrain tumor outgrowth and extend survival in glioma-bearing mice, making mCD47 delivery with FUS a promising therapeutic strategy for GB therapy.

JOURNAL OF CONTROLLED RELEASE (2021)

Review Oncology

Combination immunotherapy strategies for glioblastoma

Hok Yee Chan et al.

Summary: Despite various combination strategies involving ICB, current immunotherapies have limited efficacy in treating GBM. There is a discordance of survival outcomes between preclinical models and clinical trials, likely due to the heterogeneity of GBM in patients and other adaptive immune mechanisms. However, neoadjuvant ICB therapy in GBM has shown promising results in diversifying the TCR repertoire and increasing chemokine mRNA transcripts.

JOURNAL OF NEURO-ONCOLOGY (2021)

Article Nanoscience & Nanotechnology

Immunostimulant hydrogel for the inhibition of malignant glioma relapse post-resection

Jing Zhang et al.

Summary: The study introduces an injectable hydrogel system that stimulates tumoricidal immunity after GBM surgical resection, effectively reducing its recurrence. This system induces immunogenic cell death and sustained T-cell infiltration to attack residual tumor cells, significantly suppressing postoperative GBM recurrence.

NATURE NANOTECHNOLOGY (2021)

Review Oncology

Immunosuppression in Gliomas via PD-1/PD-L1 Axis and Adenosine Pathway

Thamiris Becker Scheffel et al.

Summary: Glioblastoma is a highly malignant subtype of glioma, and the immune landscape within the tumor microenvironment plays a crucial role in influencing therapy outcomes. The presence of multiple immunosuppression pathways, particularly the adenosine pathway, poses significant obstacles to immune-based cancer therapies and can contribute to treatment resistance. Research focusing on immune checkpoints and the adenosine pathway may provide insights into potential targets for improving tumor treatment strategies.

FRONTIERS IN ONCOLOGY (2021)

Review Immunology

Targeting Innate Immunity in Cancer Therapy

Srikrishnan Rameshbabu et al.

Summary: The majority of cancer immunotherapy strategies focus on enhancing antitumor adaptive immune responses, but the efficacy is limited to a small fraction of patients within certain tumor types. Novel approaches to activate innate immunity within the tumor microenvironment to improve antitumor immune responses have emerged, as well as rational combination strategies to activate both innate and adaptive immunity for enhanced therapeutic efficacy.

VACCINES (2021)

Review Chemistry, Medicinal

Regulation of MHC I Molecules in Glioblastoma Cells and the Sensitizing of NK Cells

Timo Burster et al.

Summary: The article summarizes the latest findings on how MHC I molecules affect NK cell surveillance of glioblastoma cells.

PHARMACEUTICALS (2021)

Review Oncology

Oncolytic Viruses: Newest Frontier for Cancer Immunotherapy

Masmudur M. Rahman et al.

Summary: Oncolytic viruses (OVs) are a novel cancer treatment modality that selectively target and kill cancer cells while sparing normal ones. Engineered OVs show great potential in clinical trials, but combination therapies with other treatments may further improve their efficacy.

CANCERS (2021)

Review Immunology

The Advantages and Challenges of Anticancer Dendritic Cell Vaccines and NK Cells in Adoptive Cell Immunotherapy

Elena V. Abakushina et al.

Summary: In the past decade, significant progress has been made in adoptive cell therapy, with dendritic cell vaccines and NK cells being potential cell preparations for cancer treatment. While NK cell immunotherapy shows high efficacy and promise against many types of cancer, there are still challenges to be overcome, such as infiltration limitations and low cytotoxic activity in solid tumors.

VACCINES (2021)

Article Cell Biology

Hypoxic glioma-derived exosomes promote M2-like macrophage polarization by enhancing autophagy induction

Jianye Xu et al.

Summary: The study reveals that glioma-derived exosomes may promote glioma proliferation and migration by inducing autophagy and M2-like macrophage polarization, leading to the formation of an immunosuppressive microenvironment. IL-6 and miR-155-3p could be novel biomarkers for diagnosing glioma, while treatments targeting autophagy and the STAT3 pathway may contribute to antitumor immunotherapy.

CELL DEATH & DISEASE (2021)

Review Genetics & Heredity

Decipher the Glioblastoma Microenvironment: The First Milestone for New Groundbreaking Therapeutic Strategies

Giuseppe Nicolo Fanelli et al.

Summary: Glioblastoma is the most common primary malignant brain tumor in adults, with poor prognosis despite novel therapeutical approaches. It is a polymorphic tumor consisting of different cells and a complex microenvironment containing various cell types and immune cells, playing a crucial role in tumor progression and treatment response. An in-depth investigation of GBM's microenvironment may lead to novel therapeutic opportunities to improve patient outcomes, especially in the field of immunotherapy.

GENES (2021)

Review Oncology

Intratumor heterogeneity, microenvironment, and mechanisms of drug resistance in glioma recurrence and evolution

Zhaoshi Bao et al.

Summary: Glioma is a common and deadly brain tumor, categorized into lower-grade gliomas and glioblastomas. Secondary glioblastoma, enriched with an isocitrate dehydrogenase mutant, typically progresses from lower-grade gliomas unlike primary glioblastoma. The mechanism of glioma recurrence and evolution patterns are different from other types of cancer, and the reasons for progression and recurrence remain controversial.

FRONTIERS OF MEDICINE (2021)

Article Cell Biology

STING agonist and IDO inhibitor combination therapy inhibits tumor progression in murine models of colorectal cancer

Jiaqi Shi et al.

Summary: The combination therapy of STING agonist diABZI and IDO inhibitor 1-MT shows significant inhibition of tumor growth in CRC, leading to increased recruitment of immune cells and decreased infiltration of suppressor cells. This combination therapy holds promise as a potential option for the treatment of CRC.

CELLULAR IMMUNOLOGY (2021)

Article Multidisciplinary Sciences

Synergistic immunotherapy of glioblastoma by dual targeting of IL-6 and CD40

Fan Yang et al.

Summary: This study demonstrates that IL-6 blockade, in combination with a CD40 agonist, overcomes macrophage-mediated immunosuppression and sensitizes glioblastoma to immune checkpoint blockade in preclinical models, providing promising opportunities for GBM and other solid tumors.

NATURE COMMUNICATIONS (2021)

Article Oncology

STING agonist loaded lipid nanoparticles overcome anti-PD-1 resistance in melanoma lung metastasis via NK cell activation

Takashi Nakamura et al.

Summary: STING-LNP treatment can overcome PD-1 resistance by activating NK cells, resulting in an increase in PD-L1 expression on cancer cells and ultimately producing a synergistic antitumor effect.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2021)

Review Oncology

STING Agonists as Cancer Therapeutics

Afsaneh Amouzegar et al.

Summary: Immunotherapies have significantly impacted cancer treatment, yet some patients do not respond effectively. Recent efforts have been focused on identifying targets that could enhance anti-tumor immune responses, with STING pathway being one novel and promising target. Research on STING agonists has opened avenues for developing more effective strategies in cancer immunotherapy.

CANCERS (2021)

Review Oncology

Tumor-Associated Microglia and Macrophages in the Glioblastoma Microenvironment and Their Implications for Therapy

Rikke Sick Andersen et al.

Summary: Glioblastoma, the most common and malignant primary brain tumor, has a poor prognosis with limited treatment options. Targeting tumor-associated microglia and macrophages (TAMs) in addition to cancer cells may be a promising therapeutic strategy. Understanding the interactions between TAMs and cancer cells is crucial for developing effective treatment approaches.

CANCERS (2021)

Review Cell Biology

Boosting Antitumor Response by Costimulatory Strategies Driven to 4-1BB and OX40 T-cell Receptors

Daniele E. Mascarelli et al.

Summary: Immunotherapy employs strategies to boost the host immune system's ability to detect and eliminate cancer cells, with costimulatory molecules playing a crucial role in the antitumor immune response.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Review Oncology

Therapeutic cancer vaccines

Mansi Saxena et al.

Summary: Therapeutic cancer vaccines aim to induce tumor regression, eradicate minimal residual disease, establish lasting anti-tumor memory, and avoid non-specific or adverse reactions. However, challenges arise due to tumor-induced immunosuppression and immunoresistance, hindering the achievement of these goals.

NATURE REVIEWS CANCER (2021)

Review Genetics & Heredity

Insights in the immunobiology of glioblastoma

Dimitrios Strepkos et al.

JOURNAL OF MOLECULAR MEDICINE-JMM (2020)

Article Biochemistry & Molecular Biology

Immune profiling of human tumors identifies CD73 as a combinatorial target in glioblastoma

Sangeeta Goswami et al.

NATURE MEDICINE (2020)

Review Oncology

Resistance to Checkpoint Inhibition in Cancer Immunotherapy

Luisa Barrueto et al.

TRANSLATIONAL ONCOLOGY (2020)

Article Oncology

Blockade of CD73 delays glioblastoma growth by modulating the immune environment

J. H. Azambuja et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2020)

Review Biochemistry & Molecular Biology

Challenges to Successful Implementation of the Immune Checkpoint Inhibitors for Treatment of Glioblastoma

Stephanie Sanders et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Biochemistry & Molecular Biology

The Role of Selected Chemokines and Their Receptors in the Development of Gliomas

Magdalena Groblewska et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Multidisciplinary Sciences

Sufficiency of CD40 activation and immune checkpoint blockade for T cell priming and tumor immunity

Alexander H. Morrison et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Article Multidisciplinary Sciences

Therapeutic modulation of phagocytosis in glioblastoma can activate both innate and adaptive antitumour immunity

Christina A. von Roemeling et al.

NATURE COMMUNICATIONS (2020)

Review Pharmacology & Pharmacy

Targeting Tumor Associated Macrophages to Overcome Conventional Treatment Resistance in Glioblastoma

Helene Gregoire et al.

FRONTIERS IN PHARMACOLOGY (2020)

Review Biochemistry & Molecular Biology

Immunotherapies and Combination Strategies for Immuno-Oncology

Cody Barbari et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Multidisciplinary Sciences

Immune phenotyping of diverse syngeneic murine brain tumors identifies immunologically distinct types

Jasneet Kaur Khalsa et al.

NATURE COMMUNICATIONS (2020)

Article Multidisciplinary Sciences

GL261 luciferase-expressing cells elicit an anti-tumor immune response: an evaluation of murine glioma models

Victoria E. Sanchez et al.

SCIENTIFIC REPORTS (2020)

Review Immunology

Immune Escape in Glioblastoma Multiforme and the Adaptation of Immunotherapies for Treatment

Joshua R. D. Pearson et al.

FRONTIERS IN IMMUNOLOGY (2020)

Review Oncology

TIGIT in cancer immunotherapy

Joe-Marc Chauvin et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2020)

Review Immunology

Treatment Progress of Immune Checkpoint Blockade Therapy for Glioblastoma

Na Zhang et al.

FRONTIERS IN IMMUNOLOGY (2020)

Review Immunology

Glioblastoma Immunotherapy Targeting the Innate Immune Checkpoint CD47-SIRPα Axis

Jinyang Hu et al.

FRONTIERS IN IMMUNOLOGY (2020)

Review Pharmacology & Pharmacy

Blood-Brain Barrier Modulation to Improve Glioma Drug Delivery

Huilong Luo et al.

PHARMACEUTICS (2020)

Review Immunology

Bacillus Calmette-Guerin (BCG) Therapy for Bladder Cancer: An Update

Sandra Guallar-Garrido et al.

IMMUNOTARGETS AND THERAPY (2020)

Review Oncology

Brain immunology and immunotherapy in brain tumours

John H. Sampson et al.

NATURE REVIEWS CANCER (2020)

Review Oncology

Immunotherapy in CNS cancers: the role of immune cell trafficking

Nivedita M. Ratnam et al.

NEURO-ONCOLOGY (2019)

Review Oncology

Current State of Immunotherapy for Treatment of Glioblastoma

Tresa McGranahan et al.

CURRENT TREATMENT OPTIONS IN ONCOLOGY (2019)

Review Neurosciences

Dexamethasone in Glioblastoma Multiforme Therapy: Mechanisms and Controversies

Marta Cenciarini et al.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2019)

Review Immunology

Turning the corner on therapeutic cancer vaccines

Robert E. Hollingsworth et al.

NPJ VACCINES (2019)

Review Biochemistry & Molecular Biology

Glioblastoma heterogeneity and the tumour microenvironment: implications for preclinical research and development of new treatments

Sally L. Perrin et al.

BIOCHEMICAL SOCIETY TRANSACTIONS (2019)

Article Oncology

Cancer Vaccines

Peter J. DeMaria et al.

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA (2019)

Review Biotechnology & Applied Microbiology

Toll-Like Receptors as Therapeutic Targets in Central Nervous System Tumors

D. M. Abarca-Merlin et al.

BIOMED RESEARCH INTERNATIONAL (2019)

Article Oncology

Predominance of M2 macrophages in gliomas leads to the suppression of local and systemic immunity

Aurobind Vidyarthi et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2019)

Review Biochemistry & Molecular Biology

PD-L1/PD-1 Axis in Glioblastoma Multiforme

Jakub Litak et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Review Biochemistry & Molecular Biology

Nasal Drug Delivery of Anticancer Drugs for the Treatment of Glioblastoma: Preclinical and Clinical Trials

Franciele Aline Bruinsmann et al.

MOLECULES (2019)

Article Pharmacology & Pharmacy

Improving In Vivo Brain Delivery of Monoclonal Antibody Using Novel Cyclic Peptides

Kavisha R. Ulapane et al.

PHARMACEUTICS (2019)

Article Oncology

Effect of combined anti-PD-1 and temozolomide therapy in glioblastoma

Junseong Park et al.

ONCOIMMUNOLOGY (2019)

Article Biochemistry & Molecular Biology

Temozolomide combined with PD-1 Antibody therapy for mouse orthotopic glioma model

Bailing Dai et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2018)

Editorial Material Immunology

Cellular origin of glioblastoma and its implication in precision therapy

Maojin Yao et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2018)

Article Oncology

T-Cell Exhaustion Signatures Vary with Tumor Type and Are Severe in Glioblastoma

Karolina Woroniecka et al.

CLINICAL CANCER RESEARCH (2018)

Review Oncology

Next generation of immune checkpoint therapy in cancer: new developments and challenges

Julian A. Marin-Acevedo et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2018)

Article Medicine, Research & Experimental

First results on survival from a large Phase 3 clinical trial of an autologous dendritic cell vaccine in newly diagnosed glioblastoma

Linda M. Liau et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2018)

News Item Oncology

Nivolumab plus ipilimumab in metastatic colorectal cancer

Elizabeth Gourd

LANCET ONCOLOGY (2018)

Review Clinical Neurology

Multidimensional communication in the microenvirons of glioblastoma

Marike L. Broekman et al.

NATURE REVIEWS NEUROLOGY (2018)

Review Clinical Neurology

WHO 2016 Classification of gliomas

P. Wesseling et al.

NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY (2018)

Review Multidisciplinary Sciences

Cancer immunotherapy using checkpoint blockade

Antoni Ribas et al.

SCIENCE (2018)

Review Respiratory System

Next generation immune-checkpoints for cancer therapy

Chiara Donini et al.

JOURNAL OF THORACIC DISEASE (2018)

Review Biochemistry & Molecular Biology

Glioblastoma Chemoresistance: The Double Play by Microenvironment and Blood-Brain Barrier

Martina Da Ros et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Review Immunology

Combining immune Checkpoint inhibitors with Conventional Cancer Therapy

Yiyi Yan et al.

FRONTIERS IN IMMUNOLOGY (2018)

Review Immunology

Microglia and macrophages in brain homeostasis and disease

Qingyun Li et al.

NATURE REVIEWS IMMUNOLOGY (2018)

Article Dermatology

Talimogene Laherparepvec (T-VEC) and Other Oncolytic Viruses for the Treatment of Melanoma

Praveen K. Bommareddy et al.

AMERICAN JOURNAL OF CLINICAL DERMATOLOGY (2017)

Review Oncology

Immunotherapy Approaches in the Treatment of Malignant Brain Tumors

Anastasie M. Dunn-Pirio et al.

CANCER (2017)

Article Oncology

An immunocompetent mouse model of human glioblastoma

Samantha Semenkow et al.

ONCOTARGET (2017)

Review Pharmacology & Pharmacy

Immune Checkpoint in Glioblastoma: Promising and Challenging

Jing Huang et al.

FRONTIERS IN PHARMACOLOGY (2017)

Review Pharmacology & Pharmacy

Engineering challenges for brain tumor immunotherapy

Johnathan G. Lyon et al.

ADVANCED DRUG DELIVERY REVIEWS (2017)

Review Oncology

A current perspective on cancer immune therapy: step-by-step approach to constructing the magic bullet

Gabriele D'Errico et al.

CLINICAL AND TRANSLATIONAL MEDICINE (2017)

Review Oncology

CTLA-4 and PD-1 Pathways Similarities, Differences, and Implications of Their Inhibition

Elizabeth I. Buchbinder et al.

AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS (2016)

Review Pharmacology & Pharmacy

CSF, blood-brain barrier, and brain drug delivery

William M. Pardridge

EXPERT OPINION ON DRUG DELIVERY (2016)

Article Immunology

Origin, fate and dynamics of macrophages at central nervous system interfaces

Tobias Goldmann et al.

NATURE IMMUNOLOGY (2016)

Review Neurosciences

The role of microglia and macrophages in glioma maintenance and progression

Dolores Hambardzumyan et al.

NATURE NEUROSCIENCE (2016)

Article Medicine, General & Internal

Nivolumab for Recurrent Squamous-Cell Carcinoma of the Head and Neck

R. L. Ferris et al.

NEW ENGLAND JOURNAL OF MEDICINE (2016)

Article Cell Biology

Anti-PD-1 antitumor immunity is enhanced by local and abrogated by systemic chemotherapy in GBM

Dimitrios Mathios et al.

SCIENCE TRANSLATIONAL MEDICINE (2016)

Article Medicine, Research & Experimental

Glioblastoma-infiltrated innate immune cells resemble M0 macrophage phenotype

Konrad Gabrusiewicz et al.

JCI INSIGHT (2016)

Article Oncology

Talimogene Laherparepvec Improves Durable Response Rate in Patients With Advanced Melanoma

Robert H. I. Andtbacka et al.

JOURNAL OF CLINICAL ONCOLOGY (2015)

Editorial Material Oncology

The role of checkpoints in the treatment of GBM

Jennifer E. Kim et al.

JOURNAL OF NEURO-ONCOLOGY (2015)

Editorial Material Oncology

The CD40/CD40L axis in glioma progression and therapy

Paul R. Walker et al.

NEURO-ONCOLOGY (2015)

Article Medicine, General & Internal

Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma

J. Larkin et al.

NEW ENGLAND JOURNAL OF MEDICINE (2015)

Article Multidisciplinary Sciences

Noninvasive brain cancer imaging with a bispecific antibody fragment, generated via click chemistry

Haiming Luo et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Review Multidisciplinary Sciences

Neoantigens in cancer immunotherapy

Ton N. Schumacher et al.

SCIENCE (2015)

Review Cell Biology

Anatomy and physiology of the blood-brain barrier

Yonatan Serlin et al.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2015)

Review Immunology

Revisiting the Mechanisms of CNS Immune Privilege

Antoine Louyeau et al.

TRENDS IN IMMUNOLOGY (2015)

Review Immunology

Clinical blockade of PD1 and LAG3-potential mechanisms of action

Linh T. Nguyen et al.

NATURE REVIEWS IMMUNOLOGY (2015)

Review Immunology

Molecular and cellular insights into T cell exhaustion

E. John Wherry et al.

NATURE REVIEWS IMMUNOLOGY (2015)

Review Pathology

Glioblastoma: From Molecular Pathology to Targeted Treatment

Timothy F. Cloughesy et al.

ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 9 (2014)

Article Oncology

Intratumoral temozolomide synergizes with immunotherapy in a T cell-dependent fashion

Sara Fritzell et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2013)

Review Oncology

The Definition of Primary and Secondary Glioblastoma

Hiroko Ohgaki et al.

CLINICAL CANCER RESEARCH (2013)

Review Immunology

Oncology Meets Immunology: The Cancer-Immunity Cycle

Daniel S. Chen et al.

IMMUNITY (2013)

Article Cell Biology

5′-ectonucleotidase mediates multiple-drug resistance in glioblastoma multiforme cells

Claudia Quezada et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2013)

Article Biochemistry & Molecular Biology

CSF-1R inhibition alters macrophage polarization and blocks glioma progression

Stephanie M. Pyonteck et al.

NATURE MEDICINE (2013)

Article Neurosciences

Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways

Katrin Kierdorf et al.

NATURE NEUROSCIENCE (2013)

Article Medicine, General & Internal

Safety and Tumor Responses with Lambrolizumab (Anti-PD-1) in Melanoma

Omid Hamid et al.

NEW ENGLAND JOURNAL OF MEDICINE (2013)

Article Multidisciplinary Sciences

Multifaceted oncolytic virus therapy for glioblastoma in an immunocompetent cancer stem cell model

Tooba A. Cheema et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Article Multidisciplinary Sciences

Anti-CD47 antibody-mediated phagocytosis of cancer by macrophages primes an effective antitumor T-cell response

Diane Tseng et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Article Medicine, General & Internal

Safety and Activity of Anti-PD-L1 Antibody in Patients with Advanced Cancer

Julie R. Brahmer et al.

NEW ENGLAND JOURNAL OF MEDICINE (2012)

Article Multidisciplinary Sciences

The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors

Stephen B. Willingham et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Article Multidisciplinary Sciences

A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells

Christian Schulz et al.

SCIENCE (2012)

Review Oncology

The blockade of immune checkpoints in cancer immunotherapy

Drew M. Pardoll

NATURE REVIEWS CANCER (2012)

Article Oncology

Immunosuppression in Patients with High-Grade Gliomas Treated with Radiation and Temozolomide

Stuart A. Grossman et al.

CLINICAL CANCER RESEARCH (2011)

Article Pharmacology & Pharmacy

Ipilimumab First Global Approval

Fiona Cameron et al.

DRUGS (2011)

Review Neurosciences

Heterogeneity of CNS myeloid cells and their roles in neurodegeneration

Marco Prinz et al.

NATURE NEUROSCIENCE (2011)

Article Medicine, Research & Experimental

Inhibition of vasculogenesis, but not angiogenesis, prevents the recurrence of glioblastoma after irradiation in mice

Mitomu Kioi et al.

JOURNAL OF CLINICAL INVESTIGATION (2010)

Article Medicine, General & Internal

Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

F. Stephen Hodi et al.

NEW ENGLAND JOURNAL OF MEDICINE (2010)

Article Medicine, General & Internal

Sipuleucel-T Immunotherapy for Castration-Resistant Prostate Cancer.

Philip W. Kantoff et al.

NEW ENGLAND JOURNAL OF MEDICINE (2010)

Article Multidisciplinary Sciences

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

Florent Ginhoux et al.

SCIENCE (2010)

Article Biochemistry & Molecular Biology

Development of a novel mouse glioma model using lentiviral vectors

Tomotoshi Marumoto et al.

NATURE MEDICINE (2009)

Editorial Material Cell Biology

The use of GEM models for experimental cancer therapeutics

Aarthi Gopinathan et al.

DISEASE MODELS & MECHANISMS (2008)

Article Biochemistry & Molecular Biology

Loss of tumor suppressor PTEN function increases B7-H1 expression and immunoresistance in glioma

Andrew T. Parsa et al.

NATURE MEDICINE (2007)

Review Immunology

CNS immune privilege: hiding in plain sight

Monica J. Carson et al.

IMMUNOLOGICAL REVIEWS (2006)

Article Medicine, General & Internal

Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma

R Stupp et al.

NEW ENGLAND JOURNAL OF MEDICINE (2005)