4.7 Article

Chloride intracellular channel 1 activity is not required for glioblastoma development but its inhibition dictates glioma stem cell responsivity to novel biguanide derivatives

Related references

Note: Only part of the references are listed.
Article Chemistry, Medicinal

Biguanides drugs: Past success stories and promising future for drug discovery

Oleksandr Grytsai et al.

Summary: This paper provides a comprehensive overview of the history and therapeutic applications of biguanides, with a focus on the mechanisms of currently marketed biguanide-containing drugs. It highlights the research progress on biguanides in oncology and discusses future perspectives for the design of new drugs.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2021)

Review Oncology

Patient-derived organoids as a predictive biomarker for treatment response in cancer patients

G. Emerens Wensink et al.

Summary: This study focuses on the use of patient-derived organoids (PDOs) as a potential predictive biomarker in the treatment of cancer patients, emphasizing the importance of individualized tumor response testing.

NPJ PRECISION ONCOLOGY (2021)

Review Health Care Sciences & Services

Transmembrane Chloride Intracellular Channel 1 (tmCLIC1) as a Potential Biomarker for Personalized Medicine

Francesca Cianci et al.

Summary: The loss of function and aberrant expression of ion channels and transporters, particularly the CLIC1 protein, play a crucial role in the development of diseases such as cancer and neurodegenerative diseases.

JOURNAL OF PERSONALIZED MEDICINE (2021)

Article Oncology

Use of metformin and outcome of patients with newly diagnosed glioblastoma: Pooled analysis

Corinna Seliger et al.

INTERNATIONAL JOURNAL OF CANCER (2020)

Review Biochemistry & Molecular Biology

Nanomedicine and Immunotherapy: A Step Further towards Precision Medicine for Glioblastoma

Neja Samec et al.

MOLECULES (2020)

Article Oncology

Metformin as Potential Therapy for High-Grade Glioma

Marek Mazurek et al.

CANCERS (2020)

Review Neurosciences

Engineering Three-Dimensional Tumor Models to Study Glioma Cancer Stem Cells and Tumor Microenvironment

Henry Ruiz-Garcia et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2020)

Article Multidisciplinary Sciences

Glioma-initiating cells at tumor edge gain signals from tumor core cells to promote their malignancy

Soniya Bastola et al.

NATURE COMMUNICATIONS (2020)

Review Oncology

Ion Channels as Therapeutic Targets in High Grade Gliomas

Michaela Griffin et al.

CANCERS (2020)

Review Pathology

Application of zebrafish to safety evaluation in drug discovery

Izuru Miyawaki

JOURNAL OF TOXICOLOGIC PATHOLOGY (2020)

Article Cell Biology

Modeling Patient-Derived Glioblastoma with Cerebral Organoids

Amanda Linkous et al.

CELL REPORTS (2019)

Editorial Material Oncology

Differences in molecular profiles of glioblastomas according to location

Craig Horbinski

NEURO-ONCOLOGY (2019)

Review Endocrinology & Metabolism

Metabolic Profiles Associated With Metformin Efficacy in Cancer

Sylvia Andrzejewski et al.

FRONTIERS IN ENDOCRINOLOGY (2018)

Article Biochemistry & Molecular Biology

A Structural Basis for Biguanide Activity

Scott A. Gabel et al.

BIOCHEMISTRY (2017)

Review Pharmacology & Pharmacy

Drug-repositioning opportunities for cancer therapy: novel molecular targets for known compounds

Roberto Wuerth et al.

DRUG DISCOVERY TODAY (2016)

Review Biochemistry & Molecular Biology

A comprehensive profile of recurrent glioblastoma

B. Campos et al.

ONCOGENE (2016)

Article Oncology

Metformin influences progression in diabetic glioblastoma patients

Sebastian Adeberg et al.

STRAHLENTHERAPIE UND ONKOLOGIE (2015)

Article Biochemistry & Molecular Biology

Effects of metformin and other biguanides on oxidative phosphorylation in mitochondria

Hannah R. Bridges et al.

BIOCHEMICAL JOURNAL (2014)

Review Medicine, General & Internal

Metformin in Patients With Type 2 Diabetes and Kidney Disease A Systematic Review

Silvio E. Inzucchi et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2014)

Article Gastroenterology & Hepatology

Chloride intracellular channel 1 regulates colon cancer cell migration and invasion through ROS/ERK pathway

Pan Wang et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2014)

Review Biotechnology & Applied Microbiology

New Molecules and Old Drugs as Emerging Approaches to Selectively Target Human Glioblastoma Cancer Stem Cells

Roberto Wuerth et al.

BIOMED RESEARCH INTERNATIONAL (2014)

Article Oncology

Functional Role of CLIC1 Ion Channel in Glioblastoma-Derived Stem/Progenitor Cells

Matteo Setti et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2013)

Article Biochemical Research Methods

Microscale thermophoresis quantifies biomolecular interactions under previously challenging conditions

Susanne A. I. Seidel et al.

METHODS (2013)

Review Pharmacology & Pharmacy

Metformin and cancer: from the old medicine cabinet to pharmacological pitfalls and prospects

Arian Emami Riedmaier et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2013)

Article Endocrinology & Metabolism

Management of Hyperglycemia in Type 2 Diabetes: A Patient-Centered Approach

Silvio E. Inzucchi et al.

DIABETES CARE (2012)

Article Oncology

Elevated expression of chloride intracellular channel 1 is correlated with poor prognosis in human gliomas

Liang Wang et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2012)

Article Cell Biology

Regulation of colon cancer cell migration and invasion by CLIC1-mediated RVD

Pan Wang et al.

MOLECULAR AND CELLULAR BIOCHEMISTRY (2012)

Article Cell & Tissue Engineering

Glioma-Initiating Cell Elimination by Metformin Activation of FOXO3 via AMPK

Atsushi Sato et al.

STEM CELLS TRANSLATIONAL MEDICINE (2012)

Article Biochemical Research Methods

RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome

Bo Li et al.

BMC BIOINFORMATICS (2011)

Review Pharmacology & Pharmacy

Clinical Pharmacokinetics of Metformin

Garry G. Graham et al.

CLINICAL PHARMACOKINETICS (2011)

Article Biochemistry & Molecular Biology

Different Response of Human Glioma Tumor-initiating Cells to Epidermal Growth Factor Receptor Kinase Inhibitors

Fabrizio Griffero et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

Review Pharmacology & Pharmacy

Zebrafish: a predictive model for assessing drug-induced toxicity

Patricia McGrath et al.

DRUG DISCOVERY TODAY (2008)

Article Biochemistry & Molecular Biology

Functional characterization of the NCC27 nuclear protein in stable transfected CHO-K1 cells

R Tonini et al.

FASEB JOURNAL (2000)