Caesalpinia bonduc (L.) Roxb. as a promising source of pharmacological compounds to treat Poly Cystic Ovary Syndrome (PCOS): A review

Ethnopharmacological relevance: Caesalpinia bonduc (L.) Roxb. [Family: Fabaceae (Caesalpiniaceae)], known as bonduc nut or fever nut, has been used in India for many years to treat fever, inflammation, diabetes, cardiovascular disorder, cancer and also for birth control. In recent years, the seeds of this plant are consumed to regulate the menstrual disorders in PCOS. Poly cystic ovary syndrome (PCOS) is one of the most common endocrinological disorders faced by women of reproductive-age in several countries. Aim of the review: This review is aimed at providing the updates on the potential of Caesalpinia bonducella in treating the major symptoms of PCOS and also highlights the future research needs. Materials and methods: All the data pertaining to the plant was collected from multiple databases like Google, Science Direct, Springer, PubMed, Reaxys, Sci Finder, Wiley Online library and Taylor and Francis without any language restrictions. Moreover, information related to PCOS treatment was obtained from native medicine practitioners and from Ayurvedic pharmacopeia of India. Results: More than 50 compounds have been identified in the seed kernels of C. bonducella so far. Seed kernel extracts rich in active compounds like bonducellin, caesalpinin, cassane furanoditerpenes, terpernoids, flavonoids and sterols are studied for their anti-diabetic, anti-hyperlipidemic, anti-cancer, anti-pyretic, and antioxidant properties. Recent literature has also attributed anti-androgenic and anti-estrogenic potential to this plant which might be helpful in regulating hyperandrogenism, the major predisposing factor contributing to various other clinical symptoms of PCOS. Conclusion: Phytochemicals in C. bonducella are effective against several ailments attributed to PCOS. However, there are no experiments done in PCOS animal models to claim the direct application of C. bonducella in PCOS treatment. Hence, further dose dependent toxicity studies are warranted in animal PCOS models and in PCOS patients to support the traditional evidence of the plants' potential to treat PCOS.

Automated summary

This study summarizes the potential therapeutic effects of Caesalpinia bonduc on the major symptoms of Polycystic Ovary Syndrome (PCOS) and highlights the future research needs. The seed kernels are rich in active compounds that can be used to treat diabetes, hyperlipidemia, cancer, etc., and have the potential to regulate PCOS symptoms. Although Caesalpinia bonduc has shown some effectiveness in treating PCOS symptoms, further animal model experiments and studies on PCOS patients are needed to confirm its therapeutic potential.