4.7 Article

Yi-Qi-Jian-Pi formula modulates the PI3K/AKT signaling pathway to attenuate acute-on-chronic liver failure by suppressing hypoxic injury and apoptosis in vivo and in vitro

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Summary: Our study demonstrated that Yi-Qi-Jian-Pi Formula effectively ameliorates liver injury in vivo and in vitro by regulating hepatocyte necroptosis, through targeting RIPK1/RIPK3-complex-dependent necroptosis via ROS signaling. This suggests a positive role for YQJPF in the treatment of ACLF.

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