Journal
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
Volume 37, Issue 1, Pages 100-108Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14756366.2021.1994558
Keywords
Antibiotics; acetyl-CoA carboxylase; fatty acid synthesis; molecular docking
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The rise of antibacterial-resistant bacteria is a major problem globally, requiring novel antibacterial agents to combat. Acetyl-CoA carboxylase (ACC) is a validated target, and SABA1 represents a potentially new class of antibiotics that can be used to combat the antibacterial resistance crisis.
The rise of antibacterial-resistant bacteria is a major problem in the United States of America and around the world. Millions of patients are infected with antimicrobial resistant bacteria each year. Novel antibacterial agents are needed to combat the growing and present crisis. Acetyl-CoA carboxylase (ACC), the multi-subunit complex which catalyses the first committed step in fatty acid synthesis, is a validated target for antibacterial agents. However, there are at present, no commercially available antibiotics that target ACC. Ethyl 4-[[2-chloro-5-(phenylcarbamoyl)phenyl]sulfonylamino]benzoate (SABA1) is a compound that has been shown to have antibacterial properties against Pseudomonas aeruginosa and Escherichia coli. SABA1 inhibits biotin carboxylase (BC), the enzyme that catalyses the first half reaction of ACC. SABA1 inhibits BC via an atypical mechanism. It binds in the biotin binding site in the presence of ADP. SABA1 represents a potentially new class of antibiotics that can be used to combat the antibacterial resistance crisis.
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