Simultaneous electrochemical determination of nitroaniline and flutamide based on iron vanadate and lanthanum vanadate nanocomposite modified electrode by voltammetric technique

The anticancer flutamide (FLU) is derived from the starting compounds of environmental pollutant 4-nitroaniline (4-NA), thereby, simultaneous electrochemical determination of FLU and 4-NA has offered the onsite monitoring of both starting and end product in pharmaceutical formulations. This work reports the simultaneous electrochemical determination of FLU and 4-NA based on FeVO4/LaVO4 electrode material. The FeVO4/LaVO4 composite is prepared by the sonochemical route and characterized by XRD, Raman, XPS, and HRTEM analysis. The FeVO4/LaVO4 shows a single crystalline nature and forms stable crystal structures with uniform distributions. The electroanalytical performances of FeVO4/LaVO4/GCE for simultaneous determination of FLU and 4-NA were done by differential pulse voltammetry (DPV) techniques. The studies have shown a low LOD of 1.3 nM for 4-NA and 2.9 nM for FLU. Furthermore, it reveals good sensitivity of about 1.85 and 1.25 mu A mu M-1 cm(-2) for 4-NA and FLU respectively. The FeVO4/LaVO4/GCE showed high selectivity with the other potential interfering compounds.

Automated summary

This study reports the simultaneous electrochemical determination of FLU and 4-NA based on FeVO4/LaVO4 electrode material, showing low LOD and good sensitivity. The FeVO4/LaVO4/GCE demonstrated high selectivity with other potential interfering compounds.