Targeted drug delivery systems to control neuroinflammation in central nervous system disorders

Neuroinflammation is a molecular and cellular process and tends to be one of the main hallmarks of neurodegenerative disorders. In this situation, astrocytes and microglia activate, and immune cells infiltrate to the brain. Any damage to the brain leads to the inflammatory response, leading to neurological dysfunction. Although inflammation has crucial roles in neurodegenerative disorders, few drug delivery systems have been studied on targeting the immune system compared to other pathogenesis mechanisms, and yet there is no effective treatment to stop most brain diseases. So, the management of neuroinflammation can be a good strategy for controlling brain diseases associated with neuroinflammation. Many targeted drug delivery systems are designed and developed to target immune cells of the central nervous system, especially microglia, and treat neuroinflammation associated with neurodegeneration disorders or brain tumors. This review article aims to discuss different targeted therapeutic and immunotherapeutic approaches to treat central nervous system disorders related to neuroinflammation.

Automated summary

Neuroinflammation is a key feature of neurodegenerative disorders, and research on drug delivery systems and treatments targeting the immune system is crucial for controlling brain diseases associated with neuroinflammation.