Gastrointestinal manifestations and possible mechanisms of COVID-19 in different periods

Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, has become a pandemic worldwide. Although COVID-19 mainly affects the respiratory system, gastrointestinal (GI) manifestations have been frequently reported in such cases, even as initial symptoms. There have been several studies on different GI manifestations in patients with mild and severe disease or in remission. In this review article we summarized different GI manifestations of COVID-19 at various disease stages and the possible mechanisms based on published literatures, as well as the significance of GI manifestations in systemic inflammatory injury.

Automated summary

COVID-19, caused by SARS-CoV-2 infection, has become a global pandemic, with gastrointestinal manifestations often reported alongside respiratory symptoms. Different GI manifestations have been studied in patients at different disease stages, highlighting the significance of these symptoms in systemic inflammatory injury.