Journal
JOURNAL OF CONTROLLED RELEASE
Volume 340, Issue -, Pages 125-135Publisher
ELSEVIER
DOI: 10.1016/j.jconrel.2021.10.024
Keywords
Microneedles; Silk fibroin; Vascular diseases; Intimal hyperplasia; Perivascular drug delivery; Vascular wraps
Funding
- Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI) - Ministry of Health & Welfare, South Korea [HI18C1237]
Ask authors/readers for more resources
This study introduces a novel silk microneedle wrap that can effectively inhibit intimal hyperplasia. By directly injecting anti-proliferation drugs at anastomosis sites while ensuring sufficient vascular exchanges, the silk microneedle wrap demonstrated positive outcomes in inhibiting neointimal formation.
Various perivascular drug delivery techniques have been demonstrated for localized post-treatment of intimal hyperplasia: a vascular inflammatory response caused by endothelial damages. Although most perivascular devices have focused on controlling the delivery duration of anti-proliferation drug, the confined and unidirectional delivery of the drug to the target tissue has become increasingly important. In addition, careful attention should also be paid to the luminal stability and the adequate exchange of vascular protein or cell between the blood vessel and extravascular tissue to avoid any side effect from the long-term application of any perivascular device. Here, a highly flexible and porous silk fibroin microneedle wrap (Silk MN wrap) is proposed to directly inject antiproliferative drug to the anastomosis sites while ensuring sufficient vascular exchanges. Drug-embedded silk MNs were transfer-molded on a highly flexible and porous silk wrap. The enhanced cell compatibility, molecular permeability, and flexibility of silk MN wrap guaranteed the structural integrity of blood vessels. Silk wrap successfully supported the silk MNs and induced multiple MN penetration to the target tissue. Over 28 days, silk MN wrap significantly inhibited intimal hyperplasia with a 62.1% reduction in neointimal formation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available