Journal
JOURNAL OF COLLOID AND INTERFACE SCIENCE
Volume 599, Issue -, Pages 676-685Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jcis.2021.04.133
Keywords
Electrosynthesis; Molecularly imprinted polymer; Carbon nanotubes; Overoxidized polypyrrole
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Funding
- Cohesion fund 2007- 2013 - APQ Ricerca Regione Puglia Programma regionale a sostegno della specializzazione intelligente e della sostenibilitasociale ed ambientale - FutureInResearch [9EC1495]
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A sensor for the determination of sulfamethoxazole (SMX) was successfully fabricated using a nanocomposite molecularly imprinted polymer (nanoMIP), showing a lower limit of detection and a wider linear range. The sensor exhibited good affinity and highly reproducible response, and could be effectively applied in milk samples.
Sulfamethoxazole (SMX) is a commonly used antibiotic which accumulation can favor the development of antimicrobial resistance. Therefore, easy and cheap system to monitor the presence of SMX are needed for human health protection. Herein we present a straightforward all electrochemical approach to fabricate a sensor based on a nanocomposite molecularly imprinted polymer (nanoMIP) for the determination of SMX. Firstly, oxidized multiwalled carbon nanotubes (oxMWCNTs) were electrochemically deposited on a polarized electrode to increase electrodic surface area up to 350%. Then, ultrathin overoxidized polypyrrole MIP in presence of SMX was electropolymerized on oxMWCNTs surface (nanoMIP). Finally, antibiotic was electrochemically removed. The obtained nanoMIP was characterized by atomic force microscopy, X-ray photoelectron spectroscopy and electrochemical techniques. The nanoMIP was used for the electrochemical detection of SMX evidencing a lower limit of detection (413 nM) and a wider linear range (1.99-10.88 mu M) with respect a non-nanostructured film. The nanoMIP evidenced also good affinity and a highly reproducible response (RSD = 1.2%). The sensor was able to determine SMX in milk samples evidencing good recovery values. The proposed approach can be also used in future to easily prepare different nanoMIP based sensors with improved performances for different target molecules thus overcoming current fabrication limits. (C) 2021 Elsevier Inc. All rights reserved.
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