NIR-driven intracellular photocatalytic oxygen-supply on metallic molybdenum carbide@N-carbon for hypoxic tumor therapy

The intracellular O-2-supply not only can relieve tumor hypoxia but also enhance the effects of photodynamic therapy (PDT). In this work, metallic Mo2C@N-carbon@PEG nanoparticles were constructed to reveal the near infrared (NIR)-photocatalytic O-2 generation and promote photodynamic therapy (PDT). Here, (NH4)(6)Mo7O24 center dot 4H(2)O nanorods and urea were adopted as resources that were calcined to obtain Mo2C@N-carbon nanoparticles (20 nm). All samples displayed high NIR absorption as well as photothermal conversion efficiency of up to 52.7 % (Mo2C@N-Carbon-3@PEG). The density functional theory calculations demonstrated the metallic characteristic of Mo2C and that the consecutive interband/intraband charge-transition was responsible for the high NIR harvest and redox ability of electron-hole pairs, making the NIR-photocatalytic O-2 and reactive oxygen species (ROS) generation. In comparison with the pure Mo2C, the heterostructure displayed twice the performance due to the enhanced charge-segregation between Mo2C and N-carbon. Given the high X-ray absorption coefficient and photothermal ability, the nanocomposite could be used in novel computer tomography and photothermal imaging contrast. Furthermore, the novel biodegradation and metabolism behaviors of nanocomposites were investigated, which were reflected as elimination from the body (mouse) via feces and urine within 14 days. The as synthesized Mo2C@N-Carbon@PEG nanocomposites integrated the dual-model imaging, intracellular O-2-supply, and phototherapy into one nanoplatform, revealing its potential for anti-cancer therapy. (C) 2021 Elsevier Inc. All rights reserved.

Automated summary

The metallic Mo2C@N-carbon@PEG nanoparticles were developed for generating near infrared (NIR)-photocatalytic O-2 and enhancing photodynamic therapy (PDT), showing potential for anti-cancer therapy integration. The nanocomposites exhibited high NIR absorption and photothermal conversion efficiency, with enhanced performance compared to pure Mo2C. The novel biodegradation and metabolism behaviors of the nanocomposites were also investigated, demonstrating elimination from the body within 14 days.