Journal
JOURNAL OF COLLOID AND INTERFACE SCIENCE
Volume 605, Issue -, Pages 296-310Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jcis.2021.07.092
Keywords
Nanoparticles; Delivery system; Stimuli-responsive; Photothermal performance; Multimodal synergistic treatment
Categories
Funding
- National Nature Science Foun-dation of China [81773643]
- Natural Science Founda-tion of Jiangsu Province of China [BK20140221]
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This study presents the design of an intelligent and versatile all-in-one therapeutic nanoplatform for co-delivering chemotherapeutic drugs and photosensitizers to enhance multimodal antitumor treatment, demonstrating excellent efficacy and tumor-targeting properties.
This paper presents the design of a new type of intelligent and versatile all-in-one therapeutic nanoplatform for the co-delivery of chemotherapeutic drugs and photosensitizers to facilitate multimodal antitumor treatment; the system is based on hyaluronic acid (HA)-modified manganese dioxide (MnO2)-enveloped hollow porous copper sulfide (CuS) nanoparticles (CuS@MnO2/HA NPs). In this system, a CuS inner shell allows for the co-loading of doxorubicin (DOX) and indocyanine green (ICG) and induces photothermal effects, and a biodegradable MnO2 external shell affords on-demand tumor microenvironment (TME)-triggered release and catalase-and Fenton-like activities. Moreover, the HA modification endows the system with a CD44 receptor-mediated tumor-targeting property. The formulated DOX and ICG co-loaded CuS@MnO2/HA (DOX/ICG-CuS@MnO2/HA) NPs were found to exhibit excellent photothermal performance both in vitro and in vivo. In addition, DOX/ICG-CuS@MnO2/HA NPs were found to display both TME and near-infrared (NIR)-responsive controlled release properties. The NPs also have a superior reactive oxygen species (ROS) generation capacity due to the combination of enhanced ICGinduced singlet oxygen and CuS@MnO2-mediated hydroxyl radicals. The cellular uptake, fluorescence imaging property, cytotoxicity, and thermal imaging of these NPs were also evaluated. In tumor bearing mice, the DOX/ICG-CuS@MnO2/HA NPs displayed a superior antitumor efficacy (2.57-fold) as compared with free DOX. Therefore, the developed DOX/ICG-CuS@MnO2/HA NPs have a great potential for use as an all-in-one nanotherapeutic agent for the efficient and precise induction of chemo/photother mal/photodynamic/chemodynamic therapy with superior antitumor efficacy and fewer side effects. (C) 2021 Published by Elsevier Inc.
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