Morpholinum Sulphate Salt Immobilized Onto Magnetic NPs Catalyzed Sonication Green Synthesis of Dihydropyrimidinones

The green and effective procedure for synthesis of 3,4-dihydropyrimidin-2(1H)-ones (DHPMs) was carried out from compound involving active methylene group, urea, and various aldehydes by using morpholinum sulphate salt immobilized onto magnetic nanoparticles as an efficient catalyst in ethanol solvent under ultrasound irradiation. Functionalized Fe3O4 as an effective and recyclable nanocatalyst was prepared and characterized using different methods including Fourier transform infrared spectroscopy (FT-IR), thermogravimetric analysis (TGA), vibrating sample magnetometry (VSM), scanning electron microscopy (SEM), transmission electron microscopy (TEM), and X-ray diffraction (XRD) techniques. The advantage of this work is the easy separation of the nanocatalyst by using an external magnet, recyclability, non-toxicity, versatility and high stability of the catalyst. Also, low reaction times and excellent yields make the present protocol very useful and attractive for the synthesis of the titled products by ultrasonic irradiation. Furthermore, the products were identified using melting points, FT-IR and H-1 NMR, spectroscopic data.

Automated summary

This study presents a green and efficient procedure for synthesizing 3,4-dihydropyrimidin-2(1H)-ones (DHPMs) using morpholinum sulphate salt immobilized onto magnetic nanoparticles as a catalyst under ultrasound irradiation in ethanol. The advantage of this method lies in the easy separation and recyclability of the nanocatalyst, as well as its non-toxicity, versatility, and high stability. The short reaction times and high yields make it a useful and attractive protocol for the synthesis of DHPMs.