Protective Activity of Two New Mixed-Ligand Coordination Polymers on Learning and Memory Function of Cerebral Ischemia Rats

In the present study, via using the mixed ligand synthesis approach, two coordination polymers (CPs) based on Cu(II) and Co(II) ions as nodes, namely, [Cu-3(L-1)(2)(1,2,4-BTC)(2)(H2O)(4)](n) (1) and [Co-3(L-2)(1,2,4-BTC)(2)(H2O)(4)](n) (2) (L-1 is 3,6-bis(imidazol-1-yl)pyridazine, L-2 is 3,6-bis(benzimidazol-1-yl)pyridazine and 1,2,4-H3BTC is benzene-1,2,4-tricarboxylic acid), were synthesized by reaction of the 1,2,4-H3BTC ligand and relevant metal salts with the aid of various nitrogen-donor co-ligands. Their application values on the cerebral ischemia were evaluated and the specific mechanism was studied simultaneously. At first, the enzyme linked immunosorbent assay (ELISA) was carried out to assess the inflammatory cytokines content released into cerebrospinal fluid. Besides, the neuro-apoptosis induced by cerebral ischemia was tested through the Annexin V-FITC Apoptosis Detection Kit.

Automated summary

In this study, coordination polymers based on Cu(II) and Co(II) ions as nodes were synthesized using the mixed ligand synthesis approach. The application values and specific mechanism of these polymers in cerebral ischemia were evaluated and studied.