Enamel matrix derivative as an adjunct to minimally invasive non-surgical treatment of intrabony defects: A randomized clinical trial

Aim To compare the efficacy of minimally invasive non-surgical technique (MINST) with or without enamel matrix derivative (EMD) in the treatment of intrabony defects <= 7 mm. Materials and methods Thirty-six patients were randomly assigned to the two groups. The control group received MINST, while the experimental MINST+EMD. Clinical measurements were recorded at baseline and at 6 and 12 months, and radiographic measurements were made at baseline and 12 months. Results All subjects completed the study, 18 in each group. Significant improvements were observed in both groups at 12 months (p < .001) with no differences in mean PD reduction (4.0 +/- 1.4 vs. 4.2 +/- 1.7 mm), CAL gain (3.5 +/- 1.4 vs. 3.4 +/- 1.6 mm), and defect resolution (1.9 +/- 1.1 vs. 1.8 +/- 0.9 mm) for the MINST and the MINST+EMD groups, respectively (p > .05). A trend for greater pocket closure (PD <= 4 mm and no BoP) was achieved with the application of EMD (77.8% vs. 55.6% sites), particularly for sites with baseline PD <= 8 mm (92.3% vs. 69.2% sites), accompanied by an increased number of successful composite outcome results (61.1% vs. 44.4% sites). Conclusions MINST demonstrates significant improvements 12 months after treatment of intrabony defects <= 7 mm. The additional application of EMD does not further improve the mean clinical or radiographic outcomes. This study is registered in (NCT03622255).

Automated summary

This study compared the efficacy of MINST and MINST+EMD in treating intrabony defects ≤ 7 mm. Both groups showed significant improvements at 12 months, with the application of EMD leading to higher pocket closure rates and more successful composite outcomes. The additional application of EMD did not further improve mean clinical or radiographic outcomes.