Journal
JOURNAL OF CLINICAL LABORATORY ANALYSIS
Volume 36, Issue 2, Pages -Publisher
WILEY
DOI: 10.1002/jcla.24226
Keywords
COVID-19; repeat positivity; negativity; RT-PCR
Categories
Funding
- Clinical Research Development Unit (CRDU) of Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
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This study describes the clinical utility of serial PCR testing in the final detection of COVID-19. The results indicate that serial PCR testing is unlikely to yield additional information.
Introduction RT-PCR is widely used as a diagnostic test for the detection of SARS-CoV-2. In this study, we aim to describe the clinical utility of serial PCR testing in the final detection of COVID-19. Method We collected multiple nasopharyngeal swab samples from patients who had negative RT-PCR test on the first day after hospitalization. RT-PCR tests were performed on the second day for all patients with initial negative result. For the patients with secondary negative results on day 2, tertiary RT-PCR tests were performed on day 3 after hospitalization. Result Among 68 patients with initial negative test results, at the end of follow-up, the mortality number was 20 (29.4%). About 33.8% of patients had subsequent positive PCR test results for the second time and 17.4% of the patients who performed third PCR test had positive result. Conclusion Based on this study, serial RT-PCR testing is unlikely to yield additional information.
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