Can myocardial work help in the therapy of resistant hypertension?

Article Cardiac & Cardiovascular Systems

Comprehensive assessment of hypertensive heart disease: cardiac magnetic resonance in focus

Marijana Tadic et al.

Summary: Arterial hypertension is the most common cardiovascular risk factor associated with cardiac remodeling, often leading to hypertensive heart disease. Echocardiography is typically used for diagnosis, but cardiac magnetic resonance (CMR) offers additional benefits such as assessing interstitial myocardial fibrosis. Timely diagnosis and treatment are crucial as regression of left ventricular hypertrophy can be achieved with adequate treatment.

HEART FAILURE REVIEWS (2021)

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Article Urology & Nephrology

Speckle-tracking echocardiography in comparison with ejection fraction for prediction of cardiovascular mortality in patients with end-stage renal disease

Janna Terhuerne et al.

Summary: In ESRD patients, global longitudinal strain (GLS) assessed by speckle-tracking echocardiography is a more accurate predictor of cardiovascular mortality compared to conventional echocardiography-derived left ventricular ejection fraction (EF).

CLINICAL KIDNEY JOURNAL (2021)

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Article Endocrinology & Metabolism

Estimated left ventricular pressure-myocardial strain loop as an index of cardiac work predicts all-cause mortality in patients receiving regular hemodialysis

Ke-Wei Chen et al.

Summary: The non-invasive method of left ventricular pressure-strain analysis can provide valuable information on cardiac function. Among end-stage kidney disease patients receiving regular hemodialysis, a novel index called CWI has been shown to be an accurate and independent predictor of all-cause mortality, outperforming traditional predictors like LVEF and GLS.

JOURNAL OF DIABETES AND ITS COMPLICATIONS (2021)

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Article Cardiac & Cardiovascular Systems

Myocardial work in Stage 1 and 2 hypertensive patients

Akshar Jaglan et al.

Summary: The study aimed to distinguish patterns of LV response in hypertensive vs. non-hypertensive patients using MW analysis. Results showed differences in GWI, GCW, and GWW between control and hypertension groups, indicating MW as an advanced assessment of LV systolic function in hypertensive patients under increased afterload conditions. This suggests MW provides a closer look at the relationship between LV pressure and contractility compared to traditional parameters like LV ejection fraction and global longitudinal strain.

EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING (2021)

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Article Radiology, Nuclear Medicine & Medical Imaging

Changes in left ventricular and atrial mechanics and function after dialysis in patients with end-stage renal disease

Xiaoyan Wang et al.

Summary: The study found that after HD in ESRD patients, some cardiac function parameters changed significantly, such as the decrease in LV end-diastolic volume and LVEF, indicating the influence of volume depletion on cardiac function. However, some parameters did not show significant changes after HD.

QUANTITATIVE IMAGING IN MEDICINE AND SURGERY (2021)

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Review Medicine, General & Internal

Myocardial Work: Methodology and Clinical Applications

Konstantinos Papadopoulos et al.

Summary: Assessing left ventricular contractility accurately is crucial in cardiac pathologies. The novel imaging tool called myocardial work, based on strain-blood pressure curves, provides detailed evaluation of LV function, incorporating pressure data for a more comprehensive assessment.

DIAGNOSTICS (2021)

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Article Cardiac & Cardiovascular Systems

Sacubitril-valsartan as a treatment for apparent resistant hypertension in patients with heart failure and preserved ejection fraction

Alice M. Jackson et al.

Summary: The study showed that sacubitril-valsartan may be effective in treating apparent resistant hypertension in patients with HFpEF, even in those who continue to have elevated blood pressure despite treatment with at least four antihypertensive drug classes, including an MRA.

EUROPEAN HEART JOURNAL (2021)

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Article Cardiac & Cardiovascular Systems