4.7 Article

Pseudonatural Products Occur Frequently in Biologically Relevant Compounds

Related references

Note: Only part of the references are listed.
Article Chemistry, Multidisciplinary

Design, Synthesis, and Biological Evaluation of Chemically and Biologically Diverse Pyrroquinoline Pseudo Natural Products

Jie Liu et al.

Summary: This study presents the design and synthesis of a collection of 155 pyrroquinoline pseudo-NPs, combining fragments characteristic of tetrahydroquinoline and pyrrolidine classes in novel arrangements. Cheminformatic analysis and biological evaluation revealed chemically diverse pseudo-NP classes with distinct bioactivity patterns, dependent on fragment connectivity and regioisomeric arrangement.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

Review Chemistry, Multidisciplinary

Pseudo Natural Products-Chemical Evolution of Natural Product Structure

George Karageorgis et al.

Summary: PNPs are compounds formed by combining NP fragments in unique ways, inheriting important biological characteristics of NPs while exhibiting unprecedented bioactivity. The importance of design principles, synthesis, and biological research on PNP scaffolds is emphasized. PNPs are considered as a human-driven branch of the evolution of natural product structure.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

Article Chemistry, Medicinal

Synthesis of Chimeric Thiazolo-Nootkatone Derivatives as Potent Antimicrobial Agents

Ibrahim S. Alkhaibari et al.

Summary: Synthesized fused-thiazole derivatives of nootkatone showed potent antimicrobial activity against Staphylococcus aureus and Enterococcus faecium, while being non-toxic to human cancer cell lines.

CHEMMEDCHEM (2021)

Article Multidisciplinary Sciences

Natural product fragment combination to performance-diverse pseudo-natural products

Michael Grigalunas et al.

Summary: Natural product structure and fragment-based compound development inspire the design of pseudo-natural products through combinations of fragments to create chemically and biologically diverse compound classes. A library of 244 pseudo-natural products was synthesized and evaluated in cell painting essays, revealing the phenotypic role of individual fragments in determining bioactivity.

NATURE COMMUNICATIONS (2021)

Article Chemistry, Multidisciplinary

Phenotyping Reveals Targets of a Pseudo-Natural-Product Autophagy Inhibitor

Daniel J. Foley et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

Article Chemistry, Multidisciplinary

Principle and design of pseudo-natural products

George Karageorgis et al.

NATURE CHEMISTRY (2020)

Article Biochemical Research Methods

SciPy 1.0: fundamental algorithms for scientific computing in Python

Pauli Virtanen et al.

NATURE METHODS (2020)

Review Plant Sciences

Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019

David J. Newman et al.

JOURNAL OF NATURAL PRODUCTS (2020)

Article Chemistry, Multidisciplinary

Too sweet: cheminformatics for deglycosylation in natural products

Jonas Schaub et al.

JOURNAL OF CHEMINFORMATICS (2020)

Review Biochemistry & Molecular Biology

Guided by evolution: from biology oriented synthesis to pseudo natural products

Gregor S. Cremosnik et al.

NATURAL PRODUCT REPORTS (2020)

Article Biochemistry & Molecular Biology

Natural product inspired optimization of a selective TRPV6 calcium channel inhibitor

Micael Rodrigues Cunha et al.

RSC MEDICINAL CHEMISTRY (2020)

Article Chemistry, Multidisciplinary

Design, Synthesis, and Phenotypic Profiling of Pyrano-Furo-Pyridone Pseudo Natural Products

Andreas Christoforow et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)

Article Chemistry, Multidisciplinary

Derivation of Rapamycin: Adventures in Natural Product Chemistry

Sylvain Cottens et al.

CHIMIA (2019)

Article Chemistry, Multidisciplinary

Synthesis of Indomorphan Pseudo-Natural Product Inhibitors of Glucose Transporters GLUT-1 and-3

Javier Ceballos et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)

Article Biochemistry & Molecular Biology

The Pseudo Natural Product Myokinasib Is a Myosin Light Chain Kinase 1 Inhibitor with Unprecedented Chemotype

Tabea Schneidewind et al.

CELL CHEMICAL BIOLOGY (2019)

Article Chemistry, Multidisciplinary

Chromopynones are pseudo natural product glucose uptake inhibitors targeting glucose transporters GLUT-1 and-3

George Karageorgis et al.

NATURE CHEMISTRY (2018)

Article Biochemistry & Molecular Biology

The ChEMBL database in 2017

Anna Gaulton et al.

NUCLEIC ACIDS RESEARCH (2017)

Article Chemistry, Medicinal

Highly Selective Dopamine D3 Receptor Antagonists with Arylated Diazaspiro Alkane Cores

Sean W. Reilly et al.

JOURNAL OF MEDICINAL CHEMISTRY (2017)

Review Biotechnology & Applied Microbiology

Twenty years on: the impact of fragments on drug discovery

Daniel A. Erlanson et al.

NATURE REVIEWS DRUG DISCOVERY (2016)

Article Chemistry, Organic

Diastereodivergent Pictet-Spengler Cyclization of Bicyclic N-Acyliminium Ions: Controlling a Quaternary Stereocenter

Benoit de Carne-Carnavalet et al.

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (2015)

Article Chemistry, Multidisciplinary

Natural-product-derived fragments for fragment-based ligand discovery

Bjoern Over et al.

NATURE CHEMISTRY (2013)

Article Biochemistry & Molecular Biology

Quantifying biogenic bias in screening libraries

Jerome Hert et al.

NATURE CHEMICAL BIOLOGY (2009)

Article Chemistry, Multidisciplinary

Discovery of a new class of inhibitors of Mycobacterium tuberculosis protein tyrosine phosphatase B by biology-oriented synthesis

Andrea Noeren-Mueller et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2008)