4.7 Article

Discovery of Small-Molecule VapC1 Nuclease Inhibitors by Virtual Screening and Scaffold Hopping from an Atomic Structure Revealing Protein-Protein Interactions with a Native VapB1 Inhibitor

Related references

Note: Only part of the references are listed.
Article Chemistry, Medicinal

Discovery and Optimization of 2H-1λ2-Pyridin-2-one Inhibitors of Mutant Isocitrate Dehydrogenase 1 for the Treatment of Cancer

Jason M. Rohde et al.

Summary: The research focused on neomorphic mutations in isocitrate dehydrogenase 1 (IDH1) and led to the discovery of a series of potent mIDH1 inhibitors, including the atropisomer (+)-119, which showed higher tumoral concentrations and lower 2-HG concentrations in an engineered mouse model compared to the approved drug AG-120.

JOURNAL OF MEDICINAL CHEMISTRY (2021)

Article Chemistry, Medicinal

Virtual Screening in the Cloud: How Big Is Big Enough?

Christoph Grebner et al.

JOURNAL OF CHEMICAL INFORMATION AND MODELING (2020)

Review Biochemistry & Molecular Biology

Toxins, Targets, and Triggers: An Overview of Toxin-Antitoxin Biology

Alexander Harms et al.

MOLECULAR CELL (2018)

Article Multidisciplinary Sciences

Assessing inhibitors of mutant isocitrate dehydrogenase using a suite of pre-clinical discovery assays

Daniel J. Urban et al.

SCIENTIFIC REPORTS (2017)

Review Biotechnology & Applied Microbiology

Combatting bacterial persister cells

Thomas K. Wood

BIOTECHNOLOGY AND BIOENGINEERING (2016)

Article Medicine, Research & Experimental

Wake me when it's over - Bacterial toxin-antitoxin proteins and induced dormancy

Nathan P. Coussens et al.

EXPERIMENTAL BIOLOGY AND MEDICINE (2016)

Review Biochemistry & Molecular Biology

Toxin-antitoxin systems in bacterial growth arrest and persistence

Rebecca Page et al.

NATURE CHEMICAL BIOLOGY (2016)

Review Microbiology

One cannot rule them all: Are bacterial toxins-antitoxins druggable?

Wai Ting Chan et al.

FEMS MICROBIOLOGY REVIEWS (2015)

Review Infectious Diseases

Non-typeable Haemophilus influenzae, an under-recognised pathogen

Johan Van Eldere et al.

LANCET INFECTIOUS DISEASES (2014)

Review Food Science & Technology

Multiple Toxin-Antitoxin Systems in Mycobacterium tuberculosis

Ambre Sala et al.

TOXINS (2014)

Review Biochemistry & Molecular Biology

Structural overview of toxin-antitoxin systems in infectious bacteria: A target for developing antimicrobial agents

Sung Jean Park et al.

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2013)

Article Biochemistry & Molecular Biology

A Bacterial Toxin Inhibits DNA Replication Elongation through a Direct Interaction with the β Sliding Clamp

Christopher D. Aakre et al.

MOLECULAR CELL (2013)

Article Chemistry, Medicinal

Discovery of RG7112: A Small-Molecule MDM2 Inhibitor in Clinical Development

Binh Vu et al.

ACS MEDICINAL CHEMISTRY LETTERS (2013)

Article Chemistry, Medicinal

Deconstruction of a Nutlin: Dissecting the Binding Determinants of a Potent Protein-Protein Interaction Inhibitor

David C. Fry et al.

ACS MEDICINAL CHEMISTRY LETTERS (2013)

Review Pharmacology & Pharmacy

Classification of scaffold-hopping approaches

Hongmao Sun et al.

DRUG DISCOVERY TODAY (2012)

Article Chemistry, Multidisciplinary

NMR Solution Structure of a Photoswitchable Apoptosis Activating Bak Peptide Bound to Bcl-xL

Piotr Wysoczanski et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2012)

Article Biochemistry & Molecular Biology

Artificial activation of toxin–antitoxin systems as an antibacterial strategy

Julia J. Williams et al.

TRENDS IN MICROBIOLOGY (2012)

Review Biochemistry & Molecular Biology

The PIN-domain ribonucleases and the prokaryotic VapBC toxin-antitoxin array

Vickery L. Arcus et al.

PROTEIN ENGINEERING DESIGN & SELECTION (2011)

Review Otorhinolaryngology

Challenges in reducing the burden of otitis media disease: An ENT perspective on improving management and prospects for prevention

Gerhard Grevers

INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY (2010)

Review Biochemistry & Molecular Biology

Pharmacophore-based virtual screening

Hongmao Sun

CURRENT MEDICINAL CHEMISTRY (2008)

Review Biochemistry & Molecular Biology

Exposing plasmids as the Achilles' heel of drug-resistant bacteria

Julia J. Williams et al.

CURRENT OPINION IN CHEMICAL BIOLOGY (2008)

Article Microbiology

VapC-1 of nontypeable Haemophilus influenzae is a ribonuclease

Dayle A. Daines et al.

JOURNAL OF BACTERIOLOGY (2007)

Article Chemistry, Medicinal

A shape-based 3-D scaffold hopping method and its application to a bacterial protein-protein interaction

TS Rush et al.

JOURNAL OF MEDICINAL CHEMISTRY (2005)

Article Biochemistry & Molecular Biology

A predictive pharmacophore model of human melanocortin-4 receptor as derived from the solution structures of cyclic peptides

HM Sun et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2004)

Article Biochemistry & Molecular Biology

MazF cleaves cellular mRNAs specifically at ACA to block protein synthesis in Escherichia coli

YL Zhang et al.

MOLECULAR CELL (2003)

Article Biochemistry & Molecular Biology

RelE toxins from Bacteria and Archaea cleave mRNAs on translating ribosomes, which are rescued by tmRNA

SK Christensen et al.

MOLECULAR MICROBIOLOGY (2003)