4.7 Review

The implications of the purinergic signaling throughout pregnancy

Journal

JOURNAL OF CELLULAR PHYSIOLOGY
Volume 237, Issue 1, Pages 507-522

Publisher

WILEY
DOI: 10.1002/jcp.30594

Keywords

Adenosine; ATP; embryo-maternal interface; placenta; pregnancy

Funding

  1. NSERC/CRSNG [262011-2009]
  2. Fundacao de Amparo a Pesquisa do Estado do Rio Grande do Sul
  3. Fonds de Recherche du Quebec -Nature et Technologies
  4. B3X postdoc fellowship
  5. Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior
  6. Conselho Nacional de Desenvolvimento Cientifico e Tecnologico [26/2020, 12/2018]

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Purinergic signaling plays a crucial role in regulating nutrient exchange, immune control, and hormonal exchange between embryo and mother during pregnancy. The modulation of ATP and adenosine on the embryo-maternal interface depends on maternal health status and is increasingly recognized for its role in modulating suboptimal pregnancy conditions.
Purinergic signaling is a necessary mechanism to trigger or even amplify cell communication. Its ligands, notably adenosine triphosphate (ATP) and adenosine, modulate specific membrane-bound receptors in virtually all human cells. Regardless of the stage of the pregnancy, cellular communication between maternal, placental, and fetal cells is the paramount mechanism to sustain its optimal status. In this review, we describe the crucial role of purinergic signaling on the regulation of the maternal-fetal trophic exchanges, immune control, and endocrine exchanges throughout pregnancy. The nature of the modulation of both ATP and adenosine on the embryo-maternal interface, going through placental invasion until birth delivery depends on the general maternal-fetal health state and consequently on the selective activation of their specific receptors. In addition, an increasing number of studies have been demonstrating the pivotal role of ATP and adenosine in modulating deleterious effects of suboptimal conditions of pregnancy. Here, we discuss the role of purinergic signaling on the balance that coordinates the embryo-maternal exchanges and a promising therapeutic venue in the context of pregnancy disorders.

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