4.6 Article

Genome sequencing and molecular characterisation of XDR Acinetobacter baumannii reveal complexities in resistance: Novel combination of sulbactam-durlobactam holds promise for therapeutic intervention

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

In silico structure evaluation of BAG3 and elucidating its association with bacterial infections through protein-protein and host-pathogen interaction analysis

Soumya Basu et al.

Summary: BAG3 is a co-chaperone protein with diverse functionalities related to cardiac diseases, cancers, and viral pathogenesis, characterized by functional regions like BAG, WW, IPV, and PXXP domains. The experimental 3D structure of BAG3 protein was predicted through in silico modelling and validated through computational tools and molecular dynamics simulation studies. The WW and PXXP domains were found to be associated with cellular cytoskeleton rearrangement and adhesion-mediated response, potentially involved in BAG3-related intracellular bacterial proliferation.

JOURNAL OF CELLULAR BIOCHEMISTRY (2022)

Article Cell Biology

Gene interaction network approach to elucidate the multidrug resistance mechanisms in the pathogenic bacterial strainProteus mirabilis

Sravan K. Miryala et al.

Summary: P. mirabilis is a common pathogen in patients with urinary tract infections, showing multidrug resistance. By analyzing the evolutionary relationship and antimicrobial resistance genes of 29 strains of P. mirabilis, researchers can develop new strategies to combat multidrug-resistant strains effectively.

JOURNAL OF CELLULAR PHYSIOLOGY (2021)

Article Pharmacology & Pharmacy

Therapeutic options for difficult-to-treat Acinetobacter baumanniiinfections: a 2020 perspective

Matteo Bassetti et al.

Summary: The treatment of severe infections due to difficult-to-treat resistance Acinetobacter baumannii is currently in a period of transition, with polymyxin-based regimens being the most commonly used approach. However, it is likely that in the next 20 years, polymyxins will be replaced by less toxic novel agents as first-line choices.

EXPERT OPINION ON PHARMACOTHERAPY (2021)

Article Chemistry, Physical

Identification of bioactive natural compounds as efficient inhibitors against Mycobacterium tuberculosis protein-targets: A molecular docking and molecular dynamics simulation study

Sravan Kumar Miryala et al.

Summary: The study selected 15 natural compounds to explore their anti-tuberculosis properties through in-silico approaches, and found that Glycyrrhizin, Swertiamarin, and Laccaic acid showed better binding affinity than classical anti-tuberculosis drugs, indicating their potential as multi-target specific alternative drug candidates.

JOURNAL OF MOLECULAR LIQUIDS (2021)

Article Microbiology

Structural Characterization of Diazabicyclooctane β-Lactam Enhancers in Complex with Penicillin-Binding Proteins PBP2 and PBP3 of Pseudomonas aeruginosa

Malligarjunan Rajavel et al.

Summary: The study on the inhibition of multidrug-resistant pathogens by a new compound and the resistance mechanisms of antibiotics may offer insights into designing novel antibiotics to combat resistant strains.
Article Biotechnology & Applied Microbiology

Highly accurate-single chromosomal complete genomes using IonTorrent and MinION sequencing of clinical pathogens

Karthick Vasudevan et al.

GENOMICS (2020)

Editorial Material Pharmacology & Pharmacy

Judging the appropriate therapy for carbapenem-resistant Acinetobacter infections

Matteo Bassetti et al.

EXPERT OPINION ON PHARMACOTHERAPY (2020)

Article Public, Environmental & Occupational Health

Insertion sequences and sequence types profile of clinical isolates of carbapenem-resistant A. baumannii collected across India over four year period

Saranya Vijayakumar et al.

JOURNAL OF INFECTION AND PUBLIC HEALTH (2020)

Article Infectious Diseases

ResFinder 4.0 for predictions of phenotypes from genotypes

Valeria Bortolaia et al.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2020)

Article Immunology

Novel cyclohexanone compound as a potential ligand against SARS-CoV-2 main-protease

Soumya Basu et al.

MICROBIAL PATHOGENESIS (2020)

Review Microbiology

New beta-Lactam-beta-Lactamase Inhibitor Combinations

Dafna Yahav et al.

CLINICAL MICROBIOLOGY REVIEWS (2020)

Review Infectious Diseases

Carbapenem-resistant Acinetobacter baumannii: in pursuit of an effective treatment

E. -T. Piperaki et al.

CLINICAL MICROBIOLOGY AND INFECTION (2019)

Article Biochemical Research Methods

RAxML-NG: a fast, scalable and user-friendly tool for maximum likelihood phylogenetic inference

Alexey M. Kozlov et al.

BIOINFORMATICS (2019)

Review Biochemistry & Molecular Biology

β-Lactamases and β-Lactamase Inhibitors in the 21st Century

Catherine L. Tooke et al.

JOURNAL OF MOLECULAR BIOLOGY (2019)

Article Biochemistry & Molecular Biology

Interactive Tree Of Life (iTOL) v4: recent updates and new developments

Ivica Letunic et al.

NUCLEIC ACIDS RESEARCH (2019)

Article Infectious Diseases

Genomic analysis of human invasive Salmonella enterica serovar Typhimurium ST313 isolate B3589 from India

Jobin John Jacob et al.

INFECTION GENETICS AND EVOLUTION (2019)

Review Infectious Diseases

Multidrug Resistant Acinetobacter baumannii: Resistance by Any Other Name Would Still be Hard to Treat

David A. Butler et al.

CURRENT INFECTIOUS DISEASE REPORTS (2019)

Article Biochemistry & Molecular Biology

CASTp 3.0: computed atlas of surface topography of proteins

Wei Tian et al.

NUCLEIC ACIDS RESEARCH (2018)

Article Biochemistry & Molecular Biology

ProTSAV: A protein tertiary structure analysis and validation server

Ankita Singh et al.

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2016)

Review Microbiology

Mobile genetic elements related to carbapenem resistance in Acinetobacter baumannii

Mariana Pagano et al.

BRAZILIAN JOURNAL OF MICROBIOLOGY (2016)

Article Biochemistry & Molecular Biology

The DynaMine webserver: predicting protein dynamics from sequence

Elisa Cilia et al.

NUCLEIC ACIDS RESEARCH (2014)

Article Biochemistry & Molecular Biology

DUET: a server for predicting effects of mutations on protein stability using an integrated computational approach

Douglas E. V. Pires et al.

NUCLEIC ACIDS RESEARCH (2014)

Article Biochemistry & Molecular Biology

GalaxyRefine: protein structure refinement driven by side-chain repacking

Lim Heo et al.

NUCLEIC ACIDS RESEARCH (2013)

Article Microbiology

A Potential Substrate Binding Conformation of β-Lactams and Insight into the Broad Spectrum of NDM-1 Activity

Qinghui Yuan et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2012)

Article Chemistry, Multidisciplinary

Avogadro: an advanced semantic chemical editor, visualization, and analysis platform

Marcus D. Hanwell et al.

JOURNAL OF CHEMINFORMATICS (2012)

Article Chemistry, Multidisciplinary

AutoDock4 and AutoDockTools4: Automated Docking with Selective Receptor Flexibility

Garrett M. Morris et al.

JOURNAL OF COMPUTATIONAL CHEMISTRY (2009)

Article Biochemistry & Molecular Biology

ProSA-web: interactive web service for the recognition of errors in three-dimensional structures of proteins

Markus Wiederstein et al.

NUCLEIC ACIDS RESEARCH (2007)

Article Biochemistry & Molecular Biology

HARMONY: a server for the assessment of protein structures

G. Pugalenthi et al.

NUCLEIC ACIDS RESEARCH (2006)

Article Chemistry, Multidisciplinary

UCSF chimera - A visualization system for exploratory research and analysis

EF Pettersen et al.

JOURNAL OF COMPUTATIONAL CHEMISTRY (2004)