Journal
JOURNAL OF CELL BIOLOGY
Volume 221, Issue 2, Pages -Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.202201002
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Funding
- Biotechnology and Biological Sciences Research Council [BB/S001123/1]
- British Heart Foundation [PG/20/6/34835]
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The study reveals a noncanonical role of eIF6 in regulating focal adhesion formation, mechanosensing, and cell mechanics, independent of its translational role.
eIF6 is known for its role as a stimulatory translation initiation factor. In this issue, Keen et al. (2022.J. Cell Biol.https://doi.org/10.1083/jcb.202005213) identify a novel, noncanonical role, whereby eIF6 regulates focal adhesion formation, mechanosensing, and cell mechanics, independent of its translational role.
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