Journal
JOURNAL OF BIOPHOTONICS
Volume 15, Issue 1, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/jbio.202100268
Keywords
cutaneous edema; diffuse reflectance spectroscopy; multispectral imaging; Raman spectroscopy; water in the skin
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Funding
- Ministry of Science and Higher Education of the Russian Federation [075-15-2020-926]
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Quantitative assessment of water content in tissues is vital for biomedicine. Different optical spectroscopy methods were compared for characterizing cutaneous edema, showing promising results for introducing quantitative optical water measurement technology to clinical settings.
Quantitative noninvasive assessment of water content in tissues is important for biomedicine. Optical spectroscopy is potentially capable of solving this problem; however, its applicability for clinical diagnostics remains questionable. The presented study compares diffuse reflectance spectroscopy, Raman spectroscopy and multispectral imaging in the characterization of cutaneous edema. The source-detector geometries for each method are selected based on Monte Carlo simulations results to detect the signal from the dermis. Then, the kinetics of the edema development is studied for two models. All methods demonstrate synchronous trends for histamine-induced edema: The water content reaches a maximum of 1 hour after histamine application and then gradually decreases. For the venous occlusion, a 51% increase in water content is observed with Raman spectroscopy. The differences in water content estimation by three methods are explained based on the light propagation model. The obtained results are essential for introducing quantitative optical water measurement technology to the clinics.
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