Journal
JOURNAL OF BIOMECHANICS
Volume 127, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.jbiomech.2021.110692
Keywords
Thrombus; Hemodynamics; Transport; Microstructure; Thrombolysis
Categories
Funding
- National Science Foundation, United States of America [ACI-1532235, ACI-1532236]
- University of Colorado Boulder, United States of America
- Colorado State University, United States of America
Ask authors/readers for more resources
This study develops a microstructure aware model for species transport within and around a macroscale thrombus, using a custom preconditioned fictitious domain formulation for thrombus-hemodynamics interactions. The research demonstrates the formation of coherent flow structures around the thrombus and characterizes species transport from bulk flow to the thrombus boundary.
Flow-mediated transport of biochemical species is central to thrombotic phenomena. Comprehensive three-dimensional modeling of flow-mediated transport around realistic macroscale thrombi poses challenges owing to their arbitrary heterogeneous microstructure. Here, we develop a microstructure aware model for species transport within and around a macroscale thrombus by devising a custom preconditioned fictitious domain formulation for thrombus-hemodynamics interactions, and coupling it with a fictitious domain advection- diffusion formulation for transport. Microstructural heterogeneities are accounted through a hybrid discrete particle-continuum approach for the thrombus interior. We present systematic numerical investigations on unsteady arterial flow within and around a three-dimensional macroscale thrombus; demonstrate the formation of coherent flow structures around the thrombus which organize advective transport; illustrate the role of the permeation processes at the thrombus boundary and subsequent intra-thrombus transport; and characterize species transport from bulk flow to the thrombus boundary and vice versa.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available