Journal
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
Volume 33, Issue 4, Pages 532-549Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/09205063.2021.1997210
Keywords
Cryogenic 3D printing; polylactic acid scaffolds; aminated modification; nanofibrous structure; bioactivity
Funding
- National Natural Science Foundation of China [21805037]
- Fujian Provincial Health and Education Project for Tackling the Key Research [2019-WJ-22]
- Natural Science Foundation of Fujian Province [2020J02033]
- Fuzhou Science and Technology Project [2020-PT-138]
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The study developed aminated modified polylactic acid nanofibrous scaffold using cryogenic 3D printing technology, effectively addressing some issues with 3D printed PLA scaffolds. Results demonstrated that the scaffold had a bioactive interface and cell adhesion capability, making it suitable for bone tissue engineering applications.
The individualized polylactic acid (PLA) scaffolds fabricated by 3D printing technique have a good application prospect in the bone tissue engineering field. However, 3D printed PLA scaffold mainly manufactured by using a Fused Deposition Modelling fabrication technique (FDM) has some disadvantages, such as having smooth surface, strong hydrophobicity, poor cell adhesion, undesirable bioactivity, the degradation and deterioration at a high temperature triggering an inflammatory response. In this work, the aminated modified polylactic acid nanofibrous scaffold prepared by cryogenic 3D printing technology is designed to provide a feasible countermeasure to solve the key problems existing at present. The prepared scaffolds were fully characterized in terms of physico-chemical and morphological analyses, and the collected results revealed that the using of the cryogenic 3D printing technology can effectively avoid the degradation and deterioration of PLA at a high temperature required by FDM technique and promote the formation of nanofibrous structures. The in vitro tests with MC3T3-E1 cells confirmed that the cell-responsive biomimetic fibrous architecture and improved hydrophilicity due to the introduction of hydrophilic active amino groups provided a bioactive interface for cell adhesion and growth. Meanwhile, the active amino groups introduced by ammonolysis reaction can act as active sites for biomineralization. Thus, the as-prepared scaffolds may hold great potential for bone tissue engineering applications.
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