Journal
JOURNAL OF BIOMATERIALS APPLICATIONS
Volume 36, Issue 6, Pages 1019-1032Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/08853282211044853
Keywords
Polyethylene glycol diacrylate hydrogel; GelMA; Alginate hydrogel; light-cured 3D printing; cartilage scaffold; tissue engineering
Funding
- High Level Talent Internationalization Training Program of Henan Province [2019004]
- Major Science and Technology Special Project of Henan Province [171100210600]
- Program of China Scholarship Council [201807045057]
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By combining two different hydrogels, a cartilage scaffold with good mechanical properties and strong biocompatibility was successfully produced, promoting cartilage formation.
Natural cartilage tissue has excellent mechanical properties and has certain cellular components. At this stage, it is a great challenge to produce cartilage scaffolds with excellent mechanical properties, biocompatibility, and biodegradability. Hydrogels are commonly used in tissue engineering because of their excellent biocompatibility; however, the mechanical properties of commonly used hydrogels are difficult to meet the requirements of making cartilage scaffolds. The mechanical properties of high concentration polyethylene glycol diacrylate (PEGDA) hydrogel are similar to those of natural cartilage, but its biocompatibility is poor. Low concentration hydrogel has better biocompatibility, but its mechanical properties are poor. In this study, two different hydrogels were combined to produce cartilage scaffolds with good mechanical properties and strong biocompatibility. First, the PEGDA grid scaffold was printed with light curing 3D printing technology, and then the low concentration GelMA/Alginate hydrogel with chondral cells was filled into the PEGDA grid scaffold. After a series of cell experiments, the filling hydrogel with the best biocompatibility was screened out, and finally the filled hydrogel with cells and excellent biocompatibility was obtained. Cartilage tissue engineering scaffolds with certain mechanical properties were found to have a tendency of cartilage formation in in vitro culture. Compared with the scaffold obtained by using a single hydrogel, this molding method can produce a tissue engineering scaffold with excellent mechanical properties on the premise of ensuring biocompatibility, which has a certain potential application value in the field of cartilage tissue engineering.
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