4.4 Article

Mono-and dinuclear zinc complexes bearing identical bis(thiosemicarbazone) ligand that exhibit alkaline phosphatase-like catalytic reactivity

Journal

JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
Volume 27, Issue 1, Pages 37-47

Publisher

SPRINGER
DOI: 10.1007/s00775-021-01909-0

Keywords

Computational chemistry; Density functional theory; Enzyme kinetics; Model compound; Hydrolysis

Funding

  1. NRF of Korea through MSIP [NRF-2020R1C1C1008886, 2021R1A2C1012851]
  2. National Research Foundation of Korea [2021R1A2C1012851] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)

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Dinuclear zinc(II) complexes can accelerate the cleavage of phosphoester bonds under basic conditions, with hydrogen bonding between water and phosphoester assisting in nucleophilic attack. These compounds exhibit fast synthetic Zn-based model performing phosphatase-like activity.
Mono-and dinuclear zinc(II) complexes bearing bis(thiosemicarbazone) (bTSC) ligand were employed in the cleavage of phosphoester bonds. Comparative kinetic studies combined with theory suggested that the P-O bond cleavage is much accelerated by dinuclear zinc(II) complex in the presence of base. Based on the DFT-optimized structures of the proposed intermediates, it is plausible that (1) the removal of sulfur atoms of bTSC ligand from the zinc center provides two vacant sites for the binding of water (or hydroxide ion) and phosphoester and (2) the H-bonding between water (or hydroxide ion) and phosphoester, through several water molecules, may also assist the P-O bond cleavage and facilitate the nucleophilic attack. The kinetic and catalytic studies on the hydrolysis of phosphoester by dinuclear zinc complex showed a much-enhanced reactivity under basic reaction conditions, reaching over 95% conversion yield within 4 h. The currently presented compounds are arguably one of the faster synthetic Zn-based model performing phosphatase-like activity presented so far. [GRAPHICS] .

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