Journal
JOURNAL OF BIOLOGICAL CHEMISTRY
Volume 298, Issue 2, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.jbc.2022.101604
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Funding
- National Institutes of Health [NS096246, DK116624, NS125884, GM067795]
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Store-operated Ca2+ entry (SOCE) is a major mechanism controlling Ca2+ signaling and Ca2+-dependent functions. The mitochondrial Ca2+ uniporter plays multiple roles in regulating SOCE, Ca2+ dynamics, transcription, and lymphocyte activation.
Store-operated Ca2+ entry (SOCE) is a major mechanism controlling Ca2+ signaling and Ca2+-dependent functions and has been implicated in immunity, cancer, and organ development. SOCE-dependent cytosolic Ca2+ signals are affected by mitochondrial Ca2+ transport through several competing mechanisms. However, how these mechanisms interact in shaping Ca2+ dynamics and regulating Ca2+-dependent functions remains unclear. In a recent issue, Yoast et al. shed light on these questions by defining multiple roles of the mitochondrial Ca2+ uniporter in regulating SOCE, Ca2+ dynamics, transcription, and lymphocyte activation.
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