Journal
JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS
Volume 37, Issue 1, Pages 28-37Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/08839115211060404
Keywords
Forcespinning; O; cochenillifera; nopal; plant-based composite; nanofibers; wound dressing
Funding
- NSF PREM award [DMR-1523577]
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This study demonstrates that combining natural bioactive compounds with biodegradable polymers can create an environment conducive to cell growth, with potential for natural active ingredients to be used as alternatives in wound dressings.
In this study, Forcespinning(R) was used to produce nanofibers composed of Opuntia cochenillifera, nopal, mucilage (N) extract, chitosan (CH), and pullulan (PL) (N/CH/PL). These nopal-incorporating nanofibers were examined for their ability to sustain adhesion and proliferation of mouse embryonic fibroblast (NIH 3T3) cells. After a 6-day incubation period, N/CH/PL nanofibers displayed robust cell proliferation, with continued cell growth after an extended incubation period of 14 days. These results demonstrate that natural bioactive compounds can be combined with biodegradable polymers to provide an enhanced environment for cell growth, suggesting potential natural active ingredients as alternatives in wound dressings.
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