Journal
JOURNAL OF BACTERIOLOGY
Volume 204, Issue 2, Pages -Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JB.00498-21
Keywords
antibiotic resistance; Gram-negative bacteria; lipopolysaccharide; membranes; mobile colistin resistance; polymyxins
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Funding
- National Institute of General Medical Sciences [R35 GM133509]
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Purcell and colleagues have discovered that inactivating a single lipid recycling enzyme leads to the accumulation of waste lipid by-products, which inhibit a key factor responsible for polymyxin resistance.
Purcell and colleagues offer new insights into a major mechanism of polymyxin resistance in Gram-negative bacteria (A. B. Purcell, B. J. Voss, and M. S. Trent, J Bacteriol 204:e00498-21, 2022, https://doi.org/10.1128/JB.00498-21). Inactivating a single lipid recycling enzyme causes accumulation of waste lipid by-products that inhibit a key factor responsible for polymyxin resistance.
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