Omicron SARS-CoV-2 variant: Unique features and their impact on pre-existing antibodies

Article Immunology

Evolutionary analysis of the Delta and Delta Plus variants of the SARS-CoV-2 viruses

Saathvik R. Kannan et al.

Summary: The study revealed differences in the mutational profile between Delta and Delta Plus variants, with Delta Plus having more high-prevalence mutations and unique signature mutations. Structural analysis showed that these mutations can weaken the interactions between the virus and antibodies.

JOURNAL OF AUTOIMMUNITY (2021)

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News Item Multidisciplinary Sciences

HEAVILY MUTATED OMICRON VARIANT PUTS SCIENTISTS ON ALERT

Ewen Callaway

NATURE (2021)

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Article Multidisciplinary Sciences

BNT162b vaccines protect rhesus macaques from SARS-CoV-2

Annette B. Vogel et al.

Summary: The two vaccine candidates, BNT162b1 and BNT162b2, developed contain modified messenger RNA encoding immunogens derived from the spike glycoprotein of SARS-CoV-2. They have shown promising immune responses in mice and rhesus macaques, with ongoing phase I trials in Germany and the USA and a global phase II/III trial for BNT162b2.

NATURE (2021)

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News Item Medicine, General & Internal

Covid-19: Omicron may be more transmissible than other variants and partly resistant to existing vaccines, scientists fear

Ingrid Torjesen

BMJ-BRITISH MEDICAL JOURNAL (2021)

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Article Biochemistry & Molecular Biology

Evolution, correlation, structural impact and dynamics of emerging SARS-CoV-2 variants

Austin N. Spratt et al.

Summary: Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) infections are still unmanageable in some parts of the world, with four variants showing increased infectiousness. Structural analysis reveals that the new variants emerged against a background of known mutations.

COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL (2021)

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Review Immunology