Journal
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
Volume 39, Issue 4, Pages 861-871Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10815-022-02434-y
Keywords
Maternal effect genes; Folliculogenesis; Oocyte competence; Embryonic genome activation; Preimplantation development
Funding
- Italian Ministry of Education, University and Research (MIUR) Dipartimenti di Eccellenza Program
- Biotechnology 'L. Spallanzani', University of Pavia
- University of Pavia
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This mini review summarizes the crucial roles played by maternally inherited factors during oocyte maturation, fertilization, and preimplantation development, with a direct or indirect effect on the acquisition or maintenance of oocyte competence.
Oocyte developmental competence is defined as the capacity of the female gamete to be fertilized and sustain development to the blastocyst stage. Epigenetic reprogramming, a correct cell division pattern, and an efficient DNA damage response are all critical events that, before embryonic genome activation, are governed by maternally inherited factors such as maternal-effect gene (MEG) products. Although these molecules are stored inside the oocyte until ovulation and exert their main role during fertilization and preimplantation development, some of them are already functioning during folliculogenesis and oocyte meiosis resumption. This mini review summarizes the crucial roles played by MEGs during oocyte maturation, fertilization, and preimplantation development with a direct/indirect effect on the acquisition or maintenance of oocyte competence. Our aim is to inspire future research on a topic with potential clinical perspectives for the prediction and treatment of female infertility.
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