Journal
JOURNAL OF APPLIED MICROBIOLOGY
Volume 132, Issue 6, Pages 4150-4169Publisher
OXFORD UNIV PRESS
DOI: 10.1111/jam.15489
Keywords
Aspergillus; biological activity; endophytic fungi; secondary metabolites
Categories
Funding
- Minia University
Ask authors/readers for more resources
Fungal endophytes, particularly those from the Aspergillus genus, have been found to produce a wide range of secondary metabolites with diverse biological activities. The chemical investigation of these endophytes may lead to the discovery of potential drug leads.
Fungi that invade plant inner tissues without inducing disease symptoms are known as fungal endophytes. They represent a promising and tremendous reservoir of natural products with valuable biological potentials for application in medicine, agriculture and industry. Among the numerous existing endophytic fungi, Aspergillus strains constitute one of the most prolific sources of secondary metabolites with diverse chemical classes and interesting biological activities. This review covers the literature of the year 2020, reporting the isolation of 202 compounds obtained from more than 10 different endophytic Aspergillus species associated with different host plants. Analysis and interpretation of the collected data revealed that chemical investigation of endophytes belonging to the genus Aspergillus may greatly contribute to the discovery of potential drug leads. The isolated metabolites were chemically various and exhibited diverse biological activities such as antibacterial, anti-cancer, anti-plasmodial, anti-inflammatory, antioxidant, immunosuppressive and antifungal activities. Moreover, adoption of advanced technology in molecular biology together with modern chemical tools is anticipated to improve the discovery of new biopharmaceuticals from this valuable microbial world in the future.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available