Journal
JOURNAL OF ALZHEIMERS DISEASE
Volume 85, Issue 4, Pages 1419-1422Publisher
IOS PRESS
DOI: 10.3233/JAD-215479
Keywords
ATP; cerebral blood flow; mitochondria; omentum
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Adequate cerebral blood flow is crucial for neuronal activity, as it enhances mitochondria function and ATP production. Age-related decrease in cerebral blood flow can lead to reduced mitochondrial activity, decrease in ATP, and neuronal activity, eventually leading to Alzheimer's disease. Placement of the omentum directly on an Alzheimer's disease brain has been found to improve cognitive function.
Normally, an adequate cerebral blood flow arrives at individual cerebral neurons in which the blood flow augments activity of intraneuronal mitochondria, which is the source of intraneuronal ATP, the energy source of cerebral neurons. With a decrease in cerebral blood flow that can occur as a function of normal aging phenomena, less blood results in decreased mitochondria, decreased ATP, and a decrease in neuronal activity, which can eventually lead to Alzheimer's disease. It has been found that placement of the omentum directly on an Alzheimer's disease brain can lead to improved cognitive function.
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