Journal
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
Volume 149, Issue 5, Pages 1504-1512Publisher
MOSBY-ELSEVIER
DOI: 10.1016/j.jaci.2022.02.004
Keywords
Chronic rhinosinusitis; antibiotics; review article
Categories
Funding
- Chronic Rhinosinusitis Integrative Studies Program grant from the National Institutes of Health, Bethesda, Md, National Institute of Allergy and Infectious Diseases [U19 AI106683]
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This review article examines the rationale for and against the use of antibiotics for treating chronic rhinosinusitis, based on current evidence and understanding of pathophysiology. It also summarizes the current guidelines.
Rhinosinusitis is one of the most common reasons for adult outpatient antibiotic prescriptions, though there is little clinical evidence to support this practice, especially for chronic rhinosinusitis. Despite considerable research, the etiology of chronic rhinosinusitis, including the pathogenic role of microbes, remains poorly understood. Rigorous studies of the efficacy of antibiotic treatment of chronic sinusitis are surprisingly few in number and the results are somewhat conflicting. This review article will review the rationales for and against the treatment of chronic rhinosinusitis with antibiotics, based on current evidence and understanding of pathophysiology, and will also summarize the current guidelines.
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