Journal
IUBMB LIFE
Volume 74, Issue 8, Pages 748-753Publisher
WILEY
DOI: 10.1002/iub.2589
Keywords
Alzheimer's disease; amyloid; neuroinflammation; synbiotics
Categories
Funding
- Ministry of Science and Technology, Taiwan [MOST 109-2320-B-010-015-MY3, MOST 110-2320-B-A49A-540, MOST 110-2321-B010-006]
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Alzheimer's disease is a neurodegenerative disease with no effective prevention or treatment, but dietary modulation of the gut-brain axis can potentially delay the progression of AD by reducing neuroinflammation and alleviating cognitive deficits.
Alzheimer's disease (AD) is a neurodegenerative disease that impairs multiple memory domains without an effective prevention or treatment approach. Amyloid plaque-induced neuroinflammation exacerbates neurodegeneration and cognitive impairment in AD. To reduce neuroinflammation, we applied prebiotics or synbiotics to modulate the gut-brain axis in the AD mouse model. AD-like deficits were reduced in mice treated with synbiotics, suggesting that dietary modulation of the gut-brain axis is a potential approach to delay AD progression.
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