Journal
INTERNATIONAL JOURNAL OF STROKE
Volume 17, Issue 7, Pages 815-819Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/17474930221077164
Keywords
Basilar artery occlusion; ischemic stroke; endovascular treatment; randomized trial
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Funding
- Beijing Dingyi Foundation (China Special Fund for Stroke Prevention and Treatment)
- Beijing Healthunion Cardio-Cerebrovascular Disease Prevention and Treatment Foundation
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The study aims to explore the efficacy and safety of EVT in patients with acute BAO and address the limitations of previous trial results.
Background and hypothesis: Recently, two multicenter randomized controlled trials (RCT) failed to show a significantly beneficial effect of endovascular treatment (EVT) in patients with acute basilar artery occlusion (BAO). However, both trials suffered from equipoise issues which may have hindered the validity of the trial results. Therefore, additional RCT studies are needed to explore the potential benefit of EVT in patients presenting with BAO. Study design: ATTENTION is an investigator-initiated, multicenter, prospective, randomized, controlled clinical trial with open-label treatment and blinded outcome assessment (PROBE) of EVT versus best medical management (BMM). The primary effect parameter is a modified Rankin Score of 0-3 at day 90. Discussion: ATTENTION will provide evidence for the efficacy and safety of EVT in stroke patients within 12 h after BAO.
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