4.5 Editorial Material

Adverse outcome pathway: a path toward better data consolidation and global co-ordination of radiation research

Related references

Note: Only part of the references are listed.
Article Biology

A case example of a radiation-relevant adverse outcome pathway to lung cancer

Vinita Chauhan et al.

Summary: Adverse Outcome Pathways (AOPs) describe how a sequence of key events starting from a molecular initiator can lead to adverse outcomes relevant to risk assessment. This framework helps organize scientific knowledge, identify potential risks, and in this case study, understand the process of lung cancer induction.

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY (2021)

Article Biology

The integration of the adverse outcome pathway framework to radiation risk assessment

Vinita Chauhan et al.

Summary: The paper discusses the concept of Adverse Outcome Pathway (AOP) and its application in the radiation field to facilitate integration of information for radiation risk assessment. Collaborative efforts are needed to systematically vet the vast amount of literature and harness data for incorporation into an AOP-based framework. AOPs can help identify knowledge gaps, coordinate research, and link key events to adverse outcomes in order to refine risk assessment related to radiation exposures.

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY (2021)

Article Biology

Biologically-based modeling of radiation risk and biomarker prevalence for papillary thyroid cancer in Japanese a-bomb survivors 1958-2005

Jan Christian Kaiser et al.

Summary: This study focused on the radiation risk of PTC, proposing the use of the CLIP2 gene as a molecular biomarker to distinguish radiogenic from sporadic PTC and developing a biologically-based risk model. By demonstrating the portability of the model concept across different cohorts and improving the determination of radiation-induced cancer probability through the two-path concept, the study confirmed and improved the understanding of radiation-induced PTC.

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY (2021)

Editorial Material Biology

Biologically based models of cancer risk in radiation research

Jan Christian Kaiser et al.

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY (2021)

Article Biology

Challenges in the quantification approach to a radiation relevant adverse outcome pathway for lung cancer

Robert Stainforth et al.

Summary: Quantification of AOP KERs highlights the importance of specific radiation types and the need for response-response focused studies to better characterize the pathway from MIE to AO. The MC study estimated the range of linear energy transfer (LET) in the secretory cell nuclei of the example lung compartment.

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY (2021)

Article Environmental Sciences

Quantification of an Adverse Outcome Pathway Network by Bayesian Regression and Bayesian Network Modeling

S. Jannicke Moe et al.

Summary: This study presents a method for quantifying adverse outcome pathways (AOPs) using a combination of regression modeling and Bayesian network modeling, demonstrating its feasibility on an experimental data set.

INTEGRATED ENVIRONMENTAL ASSESSMENT AND MANAGEMENT (2021)

Review Biology

Adverse outcome pathways, key events, and radiation risk assessment

R. Julian Preston et al.

Summary: This contribution aims to review and propose approaches for integrating data from radiation biology and epidemiology studies to enhance low-dose health risk assessment. By leveraging the AOP/KE approach, it suggests developing BBDR models for radiation-induced cancers and circulatory diseases. Tight integration of epidemiology data and radiation biology information is considered necessary to improve low-dose radiation risk estimates.

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY (2021)

Editorial Material Biology

Collaborative efforts are needed among the scientific community to advance the adverse outcome pathway concept in areas of radiation risk assessment

Vinita Chauhan et al.

Summary: This paper discusses the importance of consolidating mechanistic research to guide priority research and facilitate radiation risk assessments. Organizing data using the adverse outcome pathway (AOP) framework may improve understanding of radiation knowledge, reduce uncertainties, and benefit the field of radiation research. Collaboration is crucial for effective integration of mechanistic data and supporting radiation risk assessments.

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY (2021)

Article Biology

Bringing together scientific disciplines for collaborative undertakings: a vision for advancing the adverse outcome pathway framework

Vinita Chauhan et al.

Summary: In recent years, the grand OECD AOP program has been gradually applied to risk assessment, with potential importance. NEA's HLG-LDR is also committed to advancing the field through improving research coordination, synergies between radiological and chemical research, etc. Multidisciplinary teams, data management and machine learning tools are considered pathways to progress from weight of evidence to computational causal inference.

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY (2021)

Review Biology

Expert consultation is vital for adverse outcome pathway development: a case example of cardiovascular effects of ionizing radiation

Vinita Chauhan et al.

Summary: This article discusses the use of the AOP approach to investigate the pathways and mechanisms of radiation-induced cardiovascular diseases (CVD) and the importance of expert collaboration in constructing AOPs. Through expert consultation and collaboration, AOP development can be effectively facilitated.

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY (2021)

Article Medicine, Legal

An evaluation framework for new approach methodologies (NAMs) for human health safety assessment

Stanley T. Parish et al.

REGULATORY TOXICOLOGY AND PHARMACOLOGY (2020)

Article Toxicology

Extracting and Benchmarking Emerging Adverse Outcome Pathway Knowledge

Nathan L. Pollesch et al.

TOXICOLOGICAL SCIENCES (2019)

Article Biology

Why is the multiple stressor concept of relevance to radioecology?

B. Salbu et al.

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY (2019)

Article Environmental Sciences

Modes of action and adverse effects of gamma radiation in an aquatic macrophyte Lemna minor

Li Xie et al.

SCIENCE OF THE TOTAL ENVIRONMENT (2019)

Editorial Material Public, Environmental & Occupational Health

Cohort Profile: the EPI-CT study: a European pooled epidemiological study to quantify the risk of radiation-induced cancer from paediatric CT

Marie-Odile Bernier et al.

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY (2019)

Article Biology

Is there a role for the adverse outcome pathway framework to support radiation protection?

Vinita Chauhan et al.

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY (2019)

Article Environmental Sciences

Adverse outcome pathway networks I: Development and applications

Dries Knapen et al.

ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY (2018)

Article Pharmacology & Pharmacy

AOP-DB: A database resource for the exploration of Adverse Outcome Pathways through integrated association networks

Maureen E. Pittman et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2018)

Article Engineering, Environmental

Quantitative Adverse Outcome Pathways and Their Application to Predictive Toxicology

Rory B. Conolly et al.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2017)

Article Environmental Sciences

Advancing the Adverse Outcome Pathway Framework-An International Horizon Scanning Approach

Carlie A. LaLone et al.

ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY (2017)

Review Biology

The linear nonthreshold (LNT) model as used in radiation protection: an NCRP update

John D. Boice

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY (2017)

Article Endocrinology & Metabolism

Thyroid Cancer Following Childhood Low-Dose Radiation Exposure: A Pooled Analysis of Nine Cohorts

Jay H. Lubin et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2017)

Article Environmental Sciences

Environmental risk assessment of combined effects in aquatic ecotoxicology: A discussion paper

Jonny Beyer et al.

MARINE ENVIRONMENTAL RESEARCH (2014)

Article Toxicology

Adverse Outcome Pathway (AOP) Development I: Strategies and Principles

Daniel L. Villeneuve et al.

TOXICOLOGICAL SCIENCES (2014)

Article Environmental Sciences

ADVERSE OUTCOME PATHWAYS: A CONCEPTUAL FRAMEWORK TO SUPPORT ECOTOXICOLOGY RESEARCH AND RISK ASSESSMENT

Gerald T. Ankley et al.

ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY (2010)