4.5 Article

A million persons, a million dreams: a vision for a national center of radiation epidemiology and biology

Related references

Note: Only part of the references are listed.
Article Biology

Mortality among medical radiation workers in the United States, 1965-2016

John D. Boice et al.

Summary: This study investigated the radiation risks among medical radiation workers and found an increased risk for lung cancer, particularly among male workers. However, there were no statistically significant radiation associations with other specific causes of death such as leukemia and ischemic heart disease.

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY (2023)

Review Biology

50 Years of the Radiation Exposure Information and Reporting System

Derek Hagemeyer et al.

Summary: As the Radiation Exposure Information and Reporting System (REIRS) celebrates its 50th anniversary, it is important to recognize its role in shaping the study of occupational radiation exposure. REIRS has provided valuable dosimetry information for occupational studies and served as a crucial data source for large cohorts in the Million Person Study. Its legacy as a successful tool throughout decades of change is commendable.

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY (2022)

Review Biology

Dosimetry and uncertainty approaches for the million person study of low-dose radiation health effects: overview of the recommendations in NCRP Report No. 178

Lawrence T. Dauer et al.

Summary: The NCRP's Scientific Committee 6-9 was established to provide guidance on organ doses and their uncertainty in the Million Person Study of Low-Dose Radiation Health Effects (MPS). Their report, NCRP Report No. 178, focuses on dosimetry and uncertainty approaches for different cohorts in the MPS, providing guidelines for estimating organ doses and uncertainties in epidemiologic studies.

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY (2022)

Article Biology

Historical perspective on the department of energy mortality studies: focus on the collection and storage of individual worker data

Elizabeth D. Ellis et al.

Summary: This article presents how the Department of Energy's Comprehensive Epidemiologic Data Resource (CEDR) is integrated into the Million Person Study of Low Dose Health Effects (MPS), and demonstrates the process through a case study on scientific and maintenance workers at the Los Alamos National Laboratory.

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY (2022)

Article Biology

MPS dose reconstruction for internal emitters: some site-specific issues and approaches

Richard W. Leggett et al.

Summary: This article discusses the challenges and approaches in dose reconstructions for internal emitters in selected facilities as part of the Million Person Study (MPS). The study found that the potential errors in reconstructed tissue doses vary at different sites, with major sources of error including identification of internal emitters, intake patterns, reliability of bioassay measurements, use of coworker information, and the relation between air monitoring data and actual intake. The article provides important recommendations for improving dose reconstruction efforts, such as the development of best feasible exposure scenarios and the careful use of coworker data.

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY (2022)

Article Biology

Updated mortality analysis of the Mallinckrodt uranium processing workers, 1942-2012

Ashley P. Golden et al.

Summary: This study conducted dose-response analysis on the causes of death among early uranium processing workers and found a positive correlation between radiation dose and kidney cancer, and a negative correlation with lung cancer. Additionally, dust measurements were associated with lung diseases.

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY (2022)

Article Biology

Dosimetry for the study of medical radiation workers with a focus on the mean absorbed dose to the lung, brain and other organs

Robert C. Yoder et al.

Summary: The reconstruction of lifetime radiation doses for medical workers presents challenges due to changes in medical technology and practices, with adjustments needed to estimate mean organ absorbed doses.

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY (2022)

Article Biology

Obtaining vital status and cause of death on a million persons

Michael T. Mumma et al.

Summary: This study presents the methodology used to determine vital status and obtain cause of death (COD) in the Million Person Study of Low-Dose Health Effects (MPS). Multiple sources of vital status information were used to trace study participants, and high confirmation rates for vital status and cause of death were achieved.

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY (2022)

Article Biology

Mortality among US military participants at eight aboveground nuclear weapons test series

John D. Boice et al.

Summary: This study tracked the survival status of 114,270 nuclear weapons test participants for up to 65 years. The results showed that most atomic veterans were enlisted men who served in the Navy at the PPG and were born before 1930. The study found no statistically significant radiation associations with mortality among the participants.

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY (2022)

Article Biology

Mortality from leukemia, cancer and heart disease among US nuclear power plant workers, 1957-2011

John D. Boice et al.

Summary: The Million Person Study of Low-Dose Health Effects aims to examine the radiation risk for chronic exposures received gradually over time among nuclear power plant workers. Prolonged exposure to radiation was found to increase the risk of leukemia other than CLL among NPP workers, but there was little evidence for a radiation association with all solid cancers, lung cancer, or ischemic heart disease. Increased precision is expected as different cohorts within the MPS are combined for analysis.

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY (2022)

Review Biology

Radium dial workers: back to the future

Nicole E. Martinez et al.

Summary: This paper reviews the history of radium dial workers in the United States, discusses their work experience and the impact of radiation exposure on their health. Current epidemiological research is being conducted on the mortality of these workers, and new dosimetric models are being applied to assess radiation risks.

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY (2022)

Article Biology

Mortality among workers at the Los Alamos National Laboratory, 1943-2017

John D. Boice et al.

Summary: The study analyzed the mortality experience of 26,328 workers first employed at Los Alamos National Laboratory between 1943 and 1980, with majority being hired before 1960. Most workers had a college degree, and a significant percentage were female, white, and Hispanic. The study found little evidence of radiation increasing the risk of lung cancer or leukemia, but esophageal cancer was associated with radiation and plutonium intakes were linked to an increase in bone cancer. Non-radiation related health issues were also observed among Hispanic workers.

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY (2022)

Review Biology

Spaceflight medical countermeasures: a strategic approach for mitigating effects from solar particle events

Lisa S. Carnell

Summary: NASA has been tasked with returning humans to the lunar surface within the next five years, requiring preparation for longer distance and duration spaceflight missions than ever before. Protection from the challenging radiation environment in space is a top priority, with strategies such as physical shielding and space weather monitoring being considered. Medical countermeasures may be necessary for future human exploration missions to address radiation-induced health effects.

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY (2021)

Article Oncology

Epigenetic Age Acceleration and Chronic Health Conditions Among Adult Survivors of Childhood Cancer

Na Qin et al.

Summary: The study found that survivors of childhood cancer have significantly higher epigenetic age acceleration compared to noncancer controls, and this is associated with specific treatment exposures, unfavorable health behaviors, and the presence of specific chronic health conditions.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2021)

Article Public, Environmental & Occupational Health

Mortality among uranium miners in North America and Europe: the Pooled Uranium Miners Analysis (PUMA)

D. B. Richardson et al.

Summary: The Pooled Uranium Miners Analysis (PUMA) study found increased mortality rates among uranium miners due to various causes of death, including lung cancer and silicosis. It highlights the importance of long-term follow-up of these workers to monitor health outcomes over time.

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY (2021)

Review Biology

Adverse outcome pathways, key events, and radiation risk assessment

R. Julian Preston et al.

Summary: This contribution aims to review and propose approaches for integrating data from radiation biology and epidemiology studies to enhance low-dose health risk assessment. By leveraging the AOP/KE approach, it suggests developing BBDR models for radiation-induced cancers and circulatory diseases. Tight integration of epidemiology data and radiation biology information is considered necessary to improve low-dose radiation risk estimates.

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY (2021)

Article Environmental Sciences

Using personal monitoring data to derive organ doses for medical radiation workers in the Million Person Study-considerations regarding NCRP Commentary no. 30

C. Yoder et al.

Summary: The study focuses on evaluating the health risks of medical radiation workers exposed to low doses of radiation, including intake of radioactive elements and cancer outcomes. The research also considers differences in risks between men and women.

JOURNAL OF RADIOLOGICAL PROTECTION (2021)

Article Environmental Sciences

Cognitive effects of low dose of ionizing radiation - Lessons learned and research gaps from epidemiological and biological studies

Elisa Pasqual et al.

Summary: Research has shown that low doses of ionizing radiation can affect cognitive function, but further understanding of the mechanisms is needed. It is important to describe the specific cognitive functions or diseases that may be affected by radiation exposure. Studying individual genetic susceptibility and gene expression may help identify individuals at higher risk of cognitive effects from radiation.

ENVIRONMENT INTERNATIONAL (2021)

Article Oncology

Timing of Aspirin Use in Colorectal Cancer Chemoprevention: A Prospective Cohort Study

Yin Zhang et al.

Summary: This study found that long-term use of aspirin can play a role in colorectal cancer chemoprevention, and regular use can reduce the risk, although lower doses may be needed for long-term benefits.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2021)

Review Respiratory System

Systematic review and meta-analysis of residential radon and lung cancer in never-smokers

Elvin S. Cheng et al.

Summary: This study systematically reviewed and meta-analyzed the evidence of lung cancer risk in never-smokers associated with residential radon exposure, finding that in radon-prone areas, male never-smokers had a higher risk of lung cancer than female never-smokers. The study provided quantified risk estimates for lung cancer from residential radon exposure among both never-smokers and ever-smokers, indicating a higher risk for men among never-smokers in radon-prone areas.

EUROPEAN RESPIRATORY REVIEW (2021)

Review Medicine, General & Internal

Parkinson's disease

Bastiaan R. Bloem et al.

Summary: Parkinson's disease is a neurodegenerative condition with diverse causes and clinical presentations. Diagnosis is clinically based, and treatment goals vary from person to person, emphasizing the need for personalized management. Currently, there is no therapy to slow down or arrest the progression of Parkinson's disease.

LANCET (2021)

Review Behavioral Sciences

Progressive increase in the complexity and translatability of rodent testing to assess space-radiation induced cognitive impairment

Richard A. Britten et al.

Summary: Ground-based rodent models have shown that space radiation doses significantly impair performance in a wide range of cognitive tasks, with an increase in both complexity and translatability to humans in recent years. Advances in testing approaches and analytical methods are making ground-based studies more amenable to probabilistic risk analysis. Ongoing attempts to address knowledge gaps and the critical role of rodent studies in establishing the impact of space radiation on complex human cognitive tasks are being discussed.

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2021)

Article Biology

Lung Cancer in the Mayak Workers Cohort: Risk Estimation and Uncertainty Analysis

Daniel O. Stram et al.

Summary: This study re-examined lung cancer mortality rates among workers at the Mayak nuclear facility in Russia, finding that both external gamma-ray and internal plutonium exposures significantly increased lung cancer incidence rates when considering dose uncertainty.

RADIATION RESEARCH (2021)

Article Biotechnology & Applied Microbiology

Meta-analysis of genome-wide DNA methylation identifies shared associations across neurodegenerative disorders

Marta F. Nabais et al.

Summary: This study identified shared differentially methylated positions in whole blood between neurodegenerative disorders, indicating shared pathogenic mechanisms. Immune abnormalities caused by different neurodegenerative diseases may be interrelated to some extent.

GENOME BIOLOGY (2021)

Article Public, Environmental & Occupational Health

Occupational exposure to chronic ionizing radiation increases risk of Parkinson's disease incidence in Russian Mayak workers

Tamara V. Azizova et al.

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY (2020)

Review Biology

Internal microdosimetry of alpha-emitting radionuclides

Werner Hofmann et al.

RADIATION AND ENVIRONMENTAL BIOPHYSICS (2020)

Article Biochemistry & Molecular Biology

NASA’s first ground-based Galactic Cosmic Ray Simulator: Enabling a new era in space radiobiology research

Lisa C. Simonsen et al.

PLOS BIOLOGY (2020)

Article Environmental Sciences

Radiation epidemiology and health effects following low-level radiation exposure

J. D. Boice et al.

JOURNAL OF RADIOLOGICAL PROTECTION (2019)

Review Astronomy & Astrophysics

Advances in space radiation physics and transport at NASA

John W. Norbury et al.

LIFE SCIENCES IN SPACE RESEARCH (2019)

Article Astronomy & Astrophysics

Measurements of radiation quality factor on Mars with the Mars Science Laboratory Radiation Assessment Detector

C. Zeitlin et al.

LIFE SCIENCES IN SPACE RESEARCH (2019)

Editorial Material Environmental Sciences

Potential health effects of low dose radiation and what it means to the practice of radiation protection

Armin Ansari et al.

JOURNAL OF RADIOLOGICAL PROTECTION (2019)

Article Environmental Sciences

Mapping 241Am Spatial Distribution Within Anatomical Bone Structures Using Digital Autoradiography

George Tabatadze et al.

HEALTH PHYSICS (2019)

Article Astronomy & Astrophysics

Characterization of Solar Energetic Particle Radiation Dose to Astronaut Crew on Deep-Space Exploration Missions

Christopher J. Mertens et al.

SPACE WEATHER-THE INTERNATIONAL JOURNAL OF RESEARCH AND APPLICATIONS (2019)

Review Biochemistry & Molecular Biology

Central Nervous System Responses to Simulated Galactic Cosmic Rays

Egle Cekanaviciute et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Article Environmental Sciences

SPACE: THE FINAL FRONTIER-RESEARCH RELEVANT TO MARS

John D. Boice

HEALTH PHYSICS (2017)

Article Health Care Sciences & Services

The Minimum Data Set 3.0 Cognitive Function Scale

Kali S. Thomas et al.

MEDICAL CARE (2017)

Article Biology

Red Bone Marrow and Male Breast Doses for a Cohort of Atomic Veterans

Harold L. Beck et al.

RADIATION RESEARCH (2017)

Article Astronomy & Astrophysics

Optimal shielding thickness for galactic cosmic ray environments

Tony C. Slaba et al.

LIFE SCIENCES IN SPACE RESEARCH (2017)

Article Astronomy & Astrophysics

Reference field specification and preliminary beam selection strategy for accelerator-based GCR simulation

Tony C. Slaba et al.

LIFE SCIENCES IN SPACE RESEARCH (2016)

Article Astronomy & Astrophysics

A semiconductor radiation imaging pixel detector for space radiation dosimetry

Marti Kroupa et al.

LIFE SCIENCES IN SPACE RESEARCH (2015)

Article Public, Environmental & Occupational Health

Mortality Among a Cohort of US Commercial Airline Cockpit Crew

Lee C. Yong et al.

AMERICAN JOURNAL OF INDUSTRIAL MEDICINE (2014)

Article Environmental Sciences

RADIATION EXPOSURE OF U. S. MILITARY INDIVIDUALS

Paul K. Blake et al.

HEALTH PHYSICS (2014)

Article Public, Environmental & Occupational Health

Evidence of Confounding by Smoking of Associations Between Radiation and Lung Cancer Mortality Among Workers at the Savannah River Site

David B. Richardson et al.

AMERICAN JOURNAL OF INDUSTRIAL MEDICINE (2011)

Review Environmental Sciences

Review and evaluation of updated research on the health effects associated with low-dose ionising radiation

Lawrence T. Dauer et al.

RADIATION PROTECTION DOSIMETRY (2010)

Review Environmental Sciences

Systematic review of epidemiological studies of exposure to tritium

M. P. Little et al.

JOURNAL OF RADIOLOGICAL PROTECTION (2008)

Article Public, Environmental & Occupational Health

Are African-American nuclear workers at lower mortality risk than Caucasians?

D Wartenberg et al.

JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE (2001)

Article Clinical Neurology

Comparison of regional cerebral blood flow and glucose metabolism in the normal brain: effect of aging

M Bentourkia et al.

JOURNAL OF THE NEUROLOGICAL SCIENCES (2000)