Computational investigation of particle penetration and deposition pattern in a realistic respiratory tract model from different types of dry powder inhalers

The aim of this study was to evaluate the device performance of a new design by comparing with a typical commercial DPI. Computational fluid dynamics (CFD) coupled with the discrete element method (DEM) collision has been utilized in this study to characterize and examine the flow field and particle transportation, respectively. A typical commercial DPI and an in-house designed novel DPI with distinct design features were compared to explore their dispersion capabilities and suitability for delivery to the respiratory tract. For this exploration, realistic oral to larynx and tracheobronchial airway models consisting of bio-relevant features were adopted to enhance practical feasibility. Distinct aerosol performances were observed between the two DPIs in the respiratory tract, where the in-house DPI, in comparison with the commercial DPI, has shown approximately 30% lower deposition fraction in the mouth-throat region with approximately 7% higher escape rate in the tracheobronchial region under the identical inhalation condition. This observation demonstrates that a novel inhouse designed DPI provides higher device efficiency over the selected typical commercial DPI.

Automated summary

This study evaluated the device performance of a new design by comparing it with a typical commercial DPI. Computational fluid dynamics coupled with the discrete element method was used to characterize and examine the flow field and particle transportation. The novel in-house designed DPI showed approximately 30% lower deposition fraction in the mouth-throat region and approximately 7% higher escape rate in the tracheobronchial region compared to the commercial DPI.