Journal
INTERNATIONAL JOURNAL OF PHARMACEUTICS
Volume 608, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.ijpharm.2021.121037
Keywords
Gelatine; Bioadhesive; Polymer blend; Chemical modification; Crosslinker
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Funding
- Universiti Teknologi MARA [600-RMC/MYRA 5/3/LESTARI (018/2020)]
- Afghanistan Ministry of Higher Education (Higher Education Development Programme)
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Bioadhesive polymers are versatile in medical and pharmaceutical inventions, improving drug absorption and therapeutic outcomes. Gelatine, despite its biodegradability and biocompatibility, has limited applications due to poor adhesive properties. Strategies like chemical modification and blending with other biomaterials are proposed to enhance its bioadhesivity.
Bioadhesive polymers offer versatility to medical and pharmaceutical inventions. The incorporation of such materials to conventional dosage forms or medical devices may confer or improve the adhesivity of the bioadhesive systems, subsequently prolonging their residence time at the site of absorption or action and providing sustained release of actives with improved bioavailability and therapeutic outcomes. For decades, much focus has been put on scientific works to replace synthetic polymers with biopolymers with desirable functional properties. Gelatine has been considered one of the most promising biopolymers. Despite its biodegradability, biocompatibility and unique biological properties, gelatine exhibits poor mechanical and adhesive properties, limiting its end-use applications. The chemical modification and blending of gelatine with other biomaterials are strategies proposed to improve its bioadhesivity. Here we discuss the classical approaches involving a variety of polymer blends and composite systems containing gelatine, and gelatine modifications via thiolation, methacrylation, catechol conjugation, amination and other newly devised strategies. We highlight several of the latest studies on these strategies and their relevant findings.
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